Chelidonine, a natural product isolated and purified from the herbs of Chelidonium majus L., efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways.
Chelidonine is a benzophenanthridine alkaloid isolated from Chelidonium majus L.. Chelidonine potently induced apoptosis of Jurkat A3 T-lymphoma cells within 24 hours at a concentration of 1μM[3]. HepG2 cells also showed apoptotic features after 24 hours of chelidonine treatment (LD50 = 12μM)[4]. In human glioblastoma T98G cells, treatment with chelidonine at 0.2–1.0μM induced G2/M arrest and increased the sub-G1/0 population size in a concentration-dependent manner[5]. Chelidonine at a non-cytotoxic dose (5mg/kg) enhanced the antitumor effect of lenvatinib on the intrahepatic growth of hepatocellular carcinoma MHCC97-H cells in nude mice[6].
搜索
