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Chelidonine

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Chemical Structure| 476-32-4 同义名 : Stylophorin;Helidonine;Khelidonin
CAS号 : 476-32-4
货号 : A645441
分子式 : C20H19NO5
纯度 : 98+%
分子量 : 353.369
MDL号 : MFCD00069660
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(297.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chelidonine is a benzophenanthridine alkaloid isolated from Chelidonium majus L.. Chelidonine potently induced apoptosis of Jurkat A3 T-lymphoma cells within 24 hours at a concentration of 1μM[3]. HepG2 cells also showed apoptotic features after 24 hours of chelidonine treatment (LD50 = 12μM)[4]. In human glioblastoma T98G cells, treatment with chelidonine at 0.2–1.0μM induced G2/M arrest and increased the sub-G1/0 population size in a concentration-dependent manner[5]. Chelidonine at a non-cytotoxic dose (5mg/kg) enhanced the antitumor effect of lenvatinib on the intrahepatic growth of hepatocellular carcinoma MHCC97-H cells in nude mice[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.15mL

2.83mL

1.41mL

28.30mL

5.66mL

2.83mL
参考文献

[1]Kim O, Hwangbo C, et al. Chelidonine suppresses migration and invasion of MDA-MB-231 cells by inhibiting formation of the integrin-linked kinase/PINCH/α-parvin complex. Mol Med Rep. 2015 Aug;12(2):2161-8.

[2]Noureini SK, Esmaili H. Multiple mechanisms of cell death induced by chelidonine in MCF-7 breast cancer cell line. Chem Biol Interact. 2014 Nov 5;223:141-9.

[3]Habermehl D, Kammerer B, Handrick R, et al. Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway. BMC Cancer. 2006;6:14.

[4]Noureini SK, Wink M. Transcriptional down regulation of hTERT and senescence induction in HepG2 cells by chelidonine. World J Gastroenterol. 2009;15(29):3603-3610.

[5]Lee YK, Lee KW, Kim M, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019;2019:6318179.

[6]Hou FJ, Guo LX, Zheng KY, Song JN, Wang Q, Zheng YG. Chelidonine enhances the antitumor effect of lenvatinib on hepatocellular carcinoma cells. Onco Targets Ther. 2019;12:6685-6697.