货号:A1249406 同义名: Tinnex hydrochloride;Caroverine hydrochloride
Caroverine HCl是一种 NMDA 和 AMPA 谷氨酸受体拮抗剂,具有抗氧化和钙阻断作用,已用于耳鸣和内耳相关疾病的研究,显示出保护内耳细胞的潜力。
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免费溶解
产品名称 | AMPA receptor ↓ ↑ | GluR ↓ ↑ | mGluR5 ↓ ↑ | NMDA receptor ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
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Evans Blue | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
IEM-1754 |
+
GluR3, IC50: 6 μM GluR1, IC50: 6 μM |
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Latrepirdine 2HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
(-)-Huperzine A |
+++
AChE (G4 form), Ki: 7 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CTEP |
++++
mGlu5, IC50: 2.2 nM |
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MPEP |
++
mGluR5, IC50: 36 nM |
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Riluzole | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Caroverine HCl is a potent, competitive, and reversible NMDA and AMPA glutamate receptor antagonist. Caroverine HCl is also an antioxidant and calcium blocker with vasodilatory effects. Caroverine HCl can be used in the study of tinnitus in the inner ear[1][2][3].Caroverine HCl inhibited the pressor response of rat hindquarter preparation to potassium chloride (80 mM) and norepinephrine (1 μM) at a concentration of 1 μM for 10 minutes of treatment. Caroverine HCl markedly inhibited contraction induced by isolated rat aorta in response to potassium chloride (40 mM)[3]. |
Animal study | Caroverine HCl protects the cochlea from impulse noise trauma when administered subcutaneously at a dose of 1.44 mg/rat, 1.0 ml/hour for 72 hours[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.49mL 0.50mL 0.25mL |
12.44mL 2.49mL 1.24mL |
24.88mL 4.98mL 2.49mL |
CAS号 | 55750-05-5 |
分子式 | C22H28ClN3O2 |
分子量 | 401.93 |
别名 | Tinnex hydrochloride;Caroverine hydrochloride |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(261.24 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 20 mg/mL(49.76 mM),配合低频超声助溶 |
动物实验配方 |