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Caroverine HCl

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Chemical Structure| 55750-05-5 同义名 : Tinnex hydrochloride;Caroverine hydrochloride
CAS号 : 55750-05-5
货号 : A1249406
分子式 : C22H28ClN3O2
纯度 : 98%+
分子量 : 401.93
MDL号 : MFCD01684929
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(261.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(49.76 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Caroverine HCl is a potent, competitive, and reversible NMDA and AMPA glutamate receptor antagonist. Caroverine HCl is also an antioxidant and calcium blocker with vasodilatory effects. Caroverine HCl can be used in the study of tinnitus in the inner ear[1][2][3].Caroverine HCl inhibited the pressor response of rat hindquarter preparation to potassium chloride (80 mM) and norepinephrine (1 μM) at a concentration of 1 μM for 10 minutes of treatment. Caroverine HCl markedly inhibited contraction induced by isolated rat aorta in response to potassium chloride (40 mM)[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.49mL

0.50mL

0.25mL

12.44mL

2.49mL

1.24mL

24.88mL

4.98mL

2.49mL
参考文献

[1]Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56.

[2]Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30.

[3]Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8.

[4]Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7.