Evans blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
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HazMat fee for 500 gram (Estimated)
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Evans Blue (Direct Blue 53) inhibits L-glutamate uptake through the membrane-bound excitatory amino acid transporter (EAAT) and blocks L-glutamate and kainate receptor-mediated currents. It exhibits strong binding to serum albumin, making it a valuable tracer for high molecular weight proteins. Additionally, Evans Blue is applied in studies assessing blood-brain barrier (BBB) permeability[1].[2].
体内研究
The deposition of Evans Blue (2% solution; 4 mL/kg) in the brains of mice following intracerebral hemorrhage induced by collagenase injection was shown to be consistent regardless of the administration route of the stain[2].
体外研究
Evans Blue, a bis-azo dye, acts as a non-permeating dye that enters the cytoplasm and nucleus when plasma membrane integrity is compromised, thus staining them blue. This property is used to evaluate cell viability[1].
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