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伊文思蓝 /Evans Blue {[allProObj[0].p_purity_real_show]}

货号:A128230 同义名: Direct Blue 53;C.I. 23860

Evans Blue是一种强效广谱抗蠕虫药和驱虫药,能够改变微管结构、抑制微管蛋白聚合和破坏微管功能。Flubendodium 可阻断 STAT3 信号和自噬激活,诱导人结直肠癌 (CRC) 细胞凋亡,也可诱导 P53 表达并减少 Cyclin B1 和 p-cdc2 表达。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Evans Blue 化学结构 CAS号:314-13-6
Evans Blue 化学结构
CAS号:314-13-6
Evans Blue 3D分子结构
CAS号:314-13-6
Evans Blue 化学结构 CAS号:314-13-6
Evans Blue 3D分子结构 CAS号:314-13-6
规格 价格 会员价 库存 数量
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Evans Blue 纯度/质量文件 产品仅供科研

货号:A128230 标准纯度: {[allProObj[0].p_purity_real_show]}
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Evans Blue 生物活性

靶点
  • AMPA receptor

描述 Evans Blue (Direct Blue 53) inhibits L-glutamate uptake through the membrane-bound excitatory amino acid transporter (EAAT) and blocks L-glutamate and kainate receptor-mediated currents. It exhibits strong binding to serum albumin, making it a valuable tracer for high molecular weight proteins. Additionally, Evans Blue is applied in studies assessing blood-brain barrier (BBB) permeability[1].[2].
体内研究

The deposition of Evans Blue (2% solution; 4 mL/kg) in the brains of mice following intracerebral hemorrhage induced by collagenase injection was shown to be consistent regardless of the administration route of the stain[2].

体外研究

Evans Blue, a bis-azo dye, acts as a non-permeating dye that enters the cytoplasm and nucleus when plasma membrane integrity is compromised, thus staining them blue. This property is used to evaluate cell viability[1].

Evans Blue 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00613886 Normal Pressure Hydrocephalus Not Applicable Terminated(Funding was withdra... 展开 >>wn by Codman as expected number of patient subjects enrolled did not meet expected numbers.) 收起 << - United States, California ... 展开 >> University of California, Irvine - Medical Center Orange, California, United States, 92868 收起 <<
NCT02496013 Arteriovenous Malformation ... 展开 >> Hemangioma Neoplasms Lymph Nodes Lymphedema 收起 << Phase 1 Recruiting December 2017 China, Beijing ... 展开 >> PET centre Recruiting Beijing, Beijing, China, 100730 Contact: Jingjing Zhang, Dr.    +86 15101033017    zhangjingjingtag@163.com    Principal Investigator: Fang Li, Dr. 收起 <<
NCT01058928 - Unknown October 2010 Korea, Republic of ... 展开 >> Seoul National University Bundang Hospital Gyeonggi-do, Korea, Republic of, 463-707 收起 <<

Evans Blue 参考文献

[1]Linpeng Yao, et al. Evans Blue Dye: A Revisit of Its Applications in Biomedicine. Contrast Media Mol Imaging. 2018 Apr 22:2018:7628037.

[2]Anatol Manaenko, et al. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J Neurosci Methods. 2011 Feb 15;195(2):206-10.

Evans Blue 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.04mL

0.21mL

0.10mL

5.20mL

1.04mL

0.52mL

10.41mL

2.08mL

1.04mL

Evans Blue 技术信息

CAS号314-13-6
分子式C34H24N6Na4O14S4
分子量 960.805
别名 Direct Blue 53;C.I. 23860;T-1824
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature

溶解方案

DMSO: 25 mg/mL(26.02 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 30 mg/mL(31.22 mM),配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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