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辣椒素 /Capsaicin {[allProObj[0].p_purity_real_show]}

货号:A379804 同义名: 天然辣椒素 / (E)-Capsaicin;Vanilloid

Capsaicin is an agonist of TRPV1 with EC50 of 0.29 ± 0.05 μM in HEK293 cells. It is active component of chili peppers.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Capsaicin 化学结构 CAS号:404-86-4
Capsaicin 化学结构
CAS号:404-86-4
Capsaicin 3D分子结构
CAS号:404-86-4
Capsaicin 化学结构 CAS号:404-86-4
Capsaicin 3D分子结构 CAS号:404-86-4
规格 价格 会员价 库存 数量
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Capsaicin 纯度/质量文件 产品仅供科研

货号:A379804 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Autophagy 其他靶点 纯度
SBI-0206965 +++

ULK1, IC50: 108 nM

ULK2, IC50: 711 nM

97%
Hydroxychloroquine sulfate 99%
Valproic acid sodium HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

99%+
MRT68921 hydrochloride ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

99%+
ROC-325 99%+
Autophinib +++

Autophagy, IC50: 40 nM

97%
Lys05 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Capsaicin 生物活性

描述 Capsaicin, the active component of chili peppers, is a TRPV1 agonist with EC50 of 0.29±0.05 μM in HEK293 cells.

Capsaicin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02869867 Localized Neuropathic Pain Not Applicable Recruiting July 2019 France ... 展开 >> CHLVO de Challans Not yet recruiting Challans, France, 85300 Contact: Natacha TAILLIEZ, Nurse          CHD Vendée de la Roche sur Yon Recruiting La Roche sur Yon, France, 85925 Contact: Yves-Marie PLUCHON, PH          Clinique Brétéché Not yet recruiting Nantes, France, 44000 Contact: Audrey MILLET, Nurse 收起 <<
NCT03472677 Osteoarthritis, Knee Phase 1 Recruiting December 1, 2018 United Kingdom ... 展开 >> MAC Clinical Research Recruiting Manchester, United Kingdom Contact: Hannah Gornall, PhD 收起 <<
NCT00004316 Interstitial Cystitis ... 展开 >> Vulvar Diseases 收起 << Phase 1 Phase 2 Completed - -

Capsaicin 参考文献

[1]Fokkens W, Hellings P, et al. Capsaicin for Rhinitis. Curr Allergy Asthma Rep. 2016 Aug;16(8):60.

[2]Rollyson WD, Stover CA, et al. Bioavailability of capsaicin and its implications for drug delivery. J Control Release. 2014 Dec 28;196:96-105.

Capsaicin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.27mL

0.65mL

0.33mL

16.37mL

3.27mL

1.64mL

32.74mL

6.55mL

3.27mL

Capsaicin 技术信息

CAS号404-86-4
分子式C18H27NO3
分子量 305.412
别名 天然辣椒素 ;(E)-Capsaicin;Vanilloid;trans8MethylNvanillylnon6enamide;(E)N(4Hydroxy3methoxybenzyl)8ethylnon6enamide;C;PS;Capsicin;Capsicine;Qutenza
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

无水乙醇: 100 mg/mL(327.43 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

DMSO: 105 mg/mL(343.8 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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