Butoconazole nitrate is an anti-fungal agent and the IC50s of IL-2, TNFα, IFN and GM-CSF are 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.
Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate (MN) or clotrimazole[3]. Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis[4]. The efficacy and safety of the three-day butoconazole treatment regimen were equivalent to those of the seven-day miconazole treatment regimen[5]. The microbiologic and clinical cure rates achieved with a 3-day course of butoconazole 2% cream have been comparable with those obtained with a 6-day course of miconazole nitrate 2% cream or a 3-day course of clotrimazole vaginal tablets (200 mg/day)[6].
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