Butoconazole nitrate

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Chemical Structure| 64872-77-1 同义名 : 布康唑硝酸盐 ;RS 35887;Butoconazole (nitrate);Butoconazole, Gynazole-1, Mycelex-3, RS35887, RS-35887, RS 35887;(±)-Butoconazole
CAS号 : 64872-77-1
货号 : A114062
分子式 : C19H18Cl3N3O3S
纯度 : 99%
分子量 : 474.788
MDL号 : MFCD00058159
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(221.15 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate (MN) or clotrimazole[3]. Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis[4]. The efficacy and safety of the three-day butoconazole treatment regimen were equivalent to those of the seven-day miconazole treatment regimen[5]. The microbiologic and clinical cure rates achieved with a 3-day course of butoconazole 2% cream have been comparable with those obtained with a 6-day course of miconazole nitrate 2% cream or a 3-day course of clotrimazole vaginal tablets (200 mg/day)[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.11mL

0.42mL

0.21mL

10.53mL

2.11mL

1.05mL

21.06mL

4.21mL

2.11mL
参考文献

[1]Brown D, Henzl MR, Kaufman RH. Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group. J Reprod Med. 1999 Nov;44(11):933-8.

[2]Jacobson JB, Hajman AJ, et al. A new vaginal antifungal agent--butoconazole nitrate. Acta Obstet Gynecol Scand. 1985;64(3):241-4.

[3]Jacobson JB, Hajman AJ, Wiese J, Gandrup P, Forsström S. A new vaginal antifungal agent--butoconazole nitrate. Acta Obstet Gynecol Scand. 1985;64(3):241-4

[4]Brown D, Henzl MR, Kaufman RH. Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group. J Reprod Med. 1999 Nov;44(11):933-8

[5]Kaufman RH, Henzl MR, Brown D Jr, Horner DS, Krauss RH, Mehlisch DR, Moore DE, Prentice RL. Comparison of three-day butoconazole treatment with seven-day miconazole treatment for vulvovaginal candidiasis. J Reprod Med. 1989 Jul;34(7):479-83

[6]Adamson GD. Three-day treatment of vulvovaginal candidiasis. Am J Obstet Gynecol. 1988 Apr;158(4):1002-5