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Bicyclol

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Chemical Structure| 118159-48-1 同义名 : Bicyclol游离态 ;SY801
CAS号 : 118159-48-1
货号 : A598610
分子式 : C19H18O9
纯度 : 98%
分子量 : 390.341
MDL号 : MFCD00889471
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(269 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Bicyclol (SY 801), an anti-hepatitis medication, has demonstrated effectiveness in reducing elevated serum transaminases (ALT, AST) by about 50% in patients with chronic hepatitis B and C. It also exhibits a capacity to inhibit replication of HBV and HCV. No significant adverse reactions have been noted. When used in combination with interferon alpha, lamivudine, and adefovir dipivoxil for treating HBV or HCV, bicyclol may enhance antiviral efficacy and reduce YMDD mutants and side effects. In 2004, the China FDA approved bicyclol for production, and since then, it has been extensively employed to treat chronic HBV and HCV in China[1].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03680183 - Recruiting December 31, 2021 China, Guangdong ... 展开 >> Affiliated Cancer Hospital & Institute of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510182 Contact: Wenying Shu, PhD    86-20-66673666 ext 2006    790840799@qq.com    Contact: Tiantian Cheng, MD    86-20-66673677    gyzlgcp@163.com 收起 <<
NCT02961413 - Recruiting December 2018 China ... 展开 >> Renji hospital Recruiting Shanghai, China Contact: Yimin Mao 收起 <<
NCT02944552 Drug-Induced Acute Liver Injur... 展开 >>y 收起 << Phase 2 Recruiting August 2019 China, Beijing ... 展开 >> Beijing Chest Hospital, Capital Medical University Recruiting Beijing, Beijing, China, 101149 Contact: Naihui Chu          China, Fujian Fuzhou General Hospital of Nanjing Military Command Recruiting Fuzhou, Fujian, China, 350025 Contact: Dongliang Li          China, Shanghai Renji Hospital ，Shanghai Jiao Tong University School of Medicine Recruiting Shanghai, Shanghai, China, 200127 Contact: Yimin Mao    13003175438    maoym11968@163.com    No.85 hospital of PLA Recruiting Shanghai, Shanghai, China Contact: Chengwei Chen    13901989118    ccw2@163.com 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.81mL

2.56mL

1.28mL

25.62mL

5.12mL

2.56mL
参考文献

[1]Walsh, S.W., Y. Wang, and A. Killian, AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. J Pharmacol Exp Ther, 1999. 290(1): p. 220-6.