Bardoxolone | 齐墩果烷三萜化合物 | CDDO | Keap1-Nrf2 Activator

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巴多索隆 /Bardoxolone {[allProObj[0].p_purity_real_show]}

货号：A165469 同义名： 齐墩果烷三萜化合物 / CDDO;RTA 401

Bardoxolone是一种核因子 Nrf-2 激活剂，抑制 Z-VAD-FMK 诱导的坏死性凋亡，降低 Paclitaxel (PAC) 诱导的神经元细胞线粒体损伤。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Bardoxolone 化学结构
CAS号：218600-44-3

Bardoxolone 3D分子结构
CAS号：218600-44-3

规格	价格	会员价	库存	数量
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Bardoxolone 纯度/质量文件产品仅供科研

货号：A165469 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

NF-κB 亚型比较

产品名称	NF-κB ↓ ↑	其他靶点	纯度
PDTC ammonium	✔		98%
QNZ	++++ NF-κB, IC50: 11 nM		99%+
Sodium 4-Aminosalicylate Dihydrate	✔		98%
Sodium Salicylate	✔		95%
Parthenolide	✔	p53	97% HPLC
JSH-23	+ NF-κB, IC50: 7.1 μM		98%
Phenethyl caffeate	✔		98%
Andrographolide	✔		98+%
Curcumin	✔	Nrf2,HDAC	98%
SC75741	+++ NF-κB, EC50: 200 nM		99%+
CBL0137 HCl	++ NF-κB, EC50: 0.47 μM	p53	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Bardoxolone 生物活性

描述	Bardoxolone (CDDO) serves as a novel activator of the nuclear regulatory factor (Nrf-2), particularly beneficial for studying chronic kidney disease. Additionally, Bardoxolone acts as a potent inhibitor of necroptosis induced by Z-VAD-FMK^[1].

Bardoxolone 动物研究

Dose	Mice: 3 mg/kg^[3] (i.p.) Cynomolgus monkey: 5 mg/kg - 300 mg/kg^[4] (p.o.)
Administration	i.p., p.o.

Bardoxolone 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00529113	Pancreatic Neoplasms ... 展开 >> Pancreatic Cancer 收起 <<	Phase 1 Phase 2	Terminated(To pursue other ind... 展开 >>ications) 收起 <<	-	United States, Colorado ... 展开 >> Rocky Mountain Cancer Center (US Oncology) Denver, Colorado, United States United States, Florida Cancer Centers of Florida (US Oncology) Ocoee, Florida, United States United States, Indiana Central Indiana Cancer Centers (US Oncology) Indianapolis, Indiana, United States United States, Texas Sammons Cancer Center (US Oncology) Dallas, Texas, United States, 75246 United States, Washington Northwest Cancer Specialist- Vancouver Cancer Specialist (US Oncology) Vancouver, Washington, United States 收起 <<
NCT01500798	Chronic Kidney Disease ... 展开 >> Type 2 Diabetes 收起 <<	Phase 1	Terminated(IDMC recommendation... 展开 >> for safety concerns) 收起 <<	-	-
NCT01598363	Healthy Volunteers	Phase 1	Completed	-	United States, Wisconsin ... 展开 >> Spaulding Clinical Research, LLC West Bend, Wisconsin, United States, 53095 收起 <<

Bardoxolone 参考文献

[1]Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67(12):5865-71.

Bardoxolone 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.17mL

2.03mL

1.02mL

20.34mL

4.07mL

2.03mL

Bardoxolone 技术信息

CAS号	218600-44-3
分子式	C₃₁H₄₁NO₄
分子量	491.662

别名	齐墩果烷三萜化合物 ;CDDO;RTA 401
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(213.56 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00529113	Pancreatic Neoplasms ... 展开 >> Pancreatic Cancer 收起 <<	Phase 1 Phase 2	Terminated(To pursue other ind... 展开 >>ications) 收起 <<	-	United States, Colorado ... 展开 >> Rocky Mountain Cancer Center (US Oncology) Denver, Colorado, United States United States, Florida Cancer Centers of Florida (US Oncology) Ocoee, Florida, United States United States, Indiana Central Indiana Cancer Centers (US Oncology) Indianapolis, Indiana, United States United States, Texas Sammons Cancer Center (US Oncology) Dallas, Texas, United States, 75246 United States, Washington Northwest Cancer Specialist- Vancouver Cancer Specialist (US Oncology) Vancouver, Washington, United States 收起 <<
NCT01500798	Chronic Kidney Disease ... 展开 >> Type 2 Diabetes 收起 <<	Phase 1	Terminated(IDMC recommendation... 展开 >> for safety concerns) 收起 <<	-	-
NCT01598363	Healthy Volunteers	Phase 1	Completed	-	United States, Wisconsin ... 展开 >> Spaulding Clinical Research, LLC West Bend, Wisconsin, United States, 53095 收起 <<
NCT01689116	Healthy Volunteers	Phase 1	Completed	-	United States, Wisconsin ... 展开 >> Spaulding Clinical Research, LLC West Bend, Wisconsin, United States, 53012 收起 <<
NCT02316821	Chronic Kidney Disease ... 展开 >> Type 2 Diabetes 收起 <<	Phase 2	Completed	-	Japan ... 展开 >> Tokyo, Japan 收起 <<
NCT00529438	Advanced Solid Tumors ... 展开 >> Lymphoid Malignancies 收起 <<	Phase 1	Completed	-	United States, Massachusetts ... 展开 >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT01655186	Renal Insufficiency, Chronic ... 展开 >> Diabetes Mellitus, Type 2 收起 <<	Phase 2	Withdrawn(IDMC recommendation ... 展开 >>for safety concerns) 收起 <<	October 2013	-
NCT01576887	End-Stage Renal Disease ... 展开 >> Type 2 Diabetes Mellitus 收起 <<	Phase 2	Withdrawn(IDMC recommendation ... 展开 >>for safety concerns) 收起 <<	October 2013	-
NCT01503866	Healthy	Phase 1	Completed	-	United States, Wisconsin ... 展开 >> Covance Clinical Research Unit Madison, Wisconsin, United States, 53704 收起 <<
NCT03550443	Diabetic Kidney Disease	Phase 3	Recruiting	March 2022	Japan ... 展开 >> Japan Community Health care Organization Sendai Hospital Recruiting Sendai, Miyagi, Japan, 981-0912 收起 <<
NCT01551446	Renal Insufficiency, Chronic ... 展开 >> Diabetes Mellitus, Type 2 收起 <<	Phase 1	Withdrawn(IDMC recommendation ... 展开 >>for safety concerns) 收起 <<	October 2013	-
NCT00664027	Diabetic Nephropathy	Phase 2	Completed	-	United States, Texas ... 展开 >> West Houston Clinical Research Services Houston, Texas, United States, 77055 Renal Associates, PA San Antonio, Texas, United States, 78215 DGD Research San Antonio, Texas, United States, 78229 收起 <<
NCT01351675	Renal Insufficiency, Chronic ... 展开 >> Diabetes Mellitus, Type 2 收起 <<	Phase 3	Terminated(IDMC recommendation... 展开 >> for safety concerns) 收起 <<	-	-
NCT02036970	Pulmonary Arterial Hypertensio... 展开 >>n Pulmonary Hypertension Interstitial Lung Disease Idiopathic Interstitial Pneumonia Idiopathic Pulmonary Fibrosis Sarcoidosis Respiratory Bronchiolitis Associated Interstitial Lung Disease Desquamative Interstitial Pneumonia Cryptogenic Organizing Pneumonia Acute Interstitial Pneumonitis Idiopathic Lymphoid Interstitial Pneumonia Idiopathic Pleuroparenchymal Fibroelastosis 收起 <<	Phase 2	Completed	-	-
NCT01549769	Renal Insufficiency, Chronic ... 展开 >> Diabetes Mellitus, Type 2 收起 <<	Phase 1	Terminated(IDMC recommendation... 展开 >> for safety concerns) 收起 <<	-	-
NCT00811889	Chronic Kidney Disease ... 展开 >> Type 2 Diabetes Diabetic Nephropathy 收起 <<	Phase 2	Completed	-	-
NCT01053936	Renal Insufficiency, Chronic ... 展开 >> Diabetes Mellitus, Type 2 收起 <<	Phase 2	Completed	-	-
NCT01461161	Healthy Volunteers	Phase 1	Completed	-	United States, Wisconsin ... 展开 >> Spaulding Clinical Research West Bend, Wisconsin, United States, 53095 收起 <<
NCT02657356	Connective Tissue Disease-Asso... 展开 >>ciated Pulmonary Arterial Hypertension 收起 <<	Phase 3	Recruiting	June 2020	-
NCT03264079	Healthy Volunteers	Phase 1	Completed	-	United States, Ohio ... 展开 >> Medpace Clinical Pharmacology Unit Cincinnati, Ohio, United States, 45227 收起 <<
NCT03019185	Alport Syndrome	Phase 2 Phase 3	Active, not recruiting	December 2020	-
NCT03068130	Pulmonary Hypertension	Phase 3	Recruiting	December 2021	-
NCT03749447	Chronic Kidney Diseases ... 展开 >> Alport Syndrome 收起 <<	Phase 3	Not yet recruiting	February 2024	-
NCT01563562	Hepatic Impairment ... 展开 >> Healthy 收起 <<	Phase 1	Completed	-	United States, Florida ... 展开 >> University of Miami School of Medicine Miami, Florida, United States, 33136 United States, North Carolina Duke University Durham, North Carolina, United States, 27710 收起 <<
NCT03366337	IgA Nephropathy ... 展开 >> CKD Associated With Type 1 Diabetes Focal Segmental Glomerulosclerosis Autosomal Dominant Polycystic Kidney 收起 <<	Phase 2	Recruiting	August 2019	-

巴多索隆 /Bardoxolone {[allProObj[0].p_purity_real_show]}

Bardoxolone 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Bardoxolone 质控信息

Bardoxolone 生物活性

Bardoxolone 动物研究

Bardoxolone 临床研究

Bardoxolone 参考文献

Bardoxolone 实验方案

Bardoxolone 技术信息

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巴多索隆 /Bardoxolone {[allProObj[0].p_purity_real_show]}

Bardoxolone 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Bardoxolone 质控信息

Bardoxolone 生物活性

Bardoxolone 动物研究

Bardoxolone 临床研究

Bardoxolone 参考文献

Bardoxolone 实验方案

Bardoxolone 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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B

C

F

G

H

J

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N

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Y

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Bardoxolone 纯度/质量文件产品仅供科研