货号:A394382 同义名: Arctii;NSC 315527
Arctiin is a suppressor of cyclin D1 protein expression in multiple types of human tumor cells and also shows antiviral activity against influenza A.
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产品名称 | NF-κB ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDTC ammonium | ✔ | 98% | |||||||||||||||||
QNZ |
++++
NF-κB, IC50: 11 nM |
99%+ | |||||||||||||||||
Sodium 4-Aminosalicylate Dihydrate | ✔ | 98% | |||||||||||||||||
Sodium Salicylate | ✔ | 95% | |||||||||||||||||
Parthenolide | ✔ | p53 | 97% HPLC | ||||||||||||||||
JSH-23 |
+
NF-κB, IC50: 7.1 μM |
98% | |||||||||||||||||
Phenethyl caffeate | ✔ | 98% | |||||||||||||||||
Andrographolide | ✔ | 98+% | |||||||||||||||||
Curcumin | ✔ | Nrf2,HDAC | 98% | ||||||||||||||||
SC75741 |
+++
NF-κB, EC50: 200 nM |
99%+ | |||||||||||||||||
CBL0137 HCl |
++
NF-κB, EC50: 0.47 μM |
p53 | 99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties. It could down-regulate cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer. The dephosphorylation of the tumor-suppressor retinoblastoma protein and growth inhibition induced by arctiin could be observed in human immortalized keratinocyte HaCaT cells[7]. Combined treatment with arctiin potentiated the effect onf oseltamivir on reduction of the virus yields in both bronchoalveolar lavage fluids and lungs of mice infected with IFV (influenza A virus (A/NWS/33, H1N1))[8]. Arctiin also works as an adiponectin receptor 1 agonist with IC50 value of 1.2μM[9]. |
Dose | Rat: 30 mg/kg - 120 mg/kg[4] (p.o.) Guinea pig: 12.5 mg/kg - 50 mg/kg[5] | ||||||||||||||||
Administration | p.o. | ||||||||||||||||
Pharmacokinetics |
|
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.87mL 0.37mL 0.19mL |
9.35mL 1.87mL 0.94mL |
18.71mL 3.74mL 1.87mL |
CAS号 | 20362-31-6 |
分子式 | C27H34O11 |
分子量 | 534.552 |
别名 | Arctii;NSC 315527;Arctigenin-4-glucoside |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,Store in freezer, under -20°C |
溶解度 |
DMSO: 250 mg/mL(467.68 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 10 mg/mL(18.71 mM),配合低频超声,并水浴加热至45℃助溶 |
动物实验配方 |