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Arctiin

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Chemical Structure| 20362-31-6 同义名 : Arctii;NSC 315527;Arctigenin-4-glucoside
CAS号 : 20362-31-6
货号 : A394382
分子式 : C27H34O11
纯度 : 99%+
分子量 : 534.552
MDL号 : MFCD00870630
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(467.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(18.71 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties. It could down-regulate cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer. The dephosphorylation of the tumor-suppressor retinoblastoma protein and growth inhibition induced by arctiin could be observed in human immortalized keratinocyte HaCaT cells[7]. Combined treatment with arctiin potentiated the effect onf oseltamivir on reduction of the virus yields in both bronchoalveolar lavage fluids and lungs of mice infected with IFV (influenza A virus (A/NWS/33, H1N1))[8]. Arctiin also works as an adiponectin receptor 1 agonist with IC50 value of 1.2μM[9].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.35mL

1.87mL

0.94mL

18.71mL

3.74mL

1.87mL
参考文献

[1]Matsuzaki Y, Koyama M, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7.

[2]Hayashi K, Narutaki K, et al. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205.

[3]Sun Y, Zang Z, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354.

[4]Wu JG, Wu JZ, et al. Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 2009 Nov;16(11):1033-41.

[5]Lee JH, Lee JY, et al. Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs. Phytother Res. 2011 Mar;25(3):387-95.

[6]He F, Dou DQ, et al. Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS. Planta Med. 2012 May;78(8):800-6.

[7]Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7. PMID: 18288407.

[8]Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205. doi: 10.1248/bpb.33.1199. PMID: 20606313.

[9]Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354. doi: 10.1371/journal.pone.0063354. PMID: 23691032; PMCID: PMC3653934.