泽泻醇B /Alisol B {[allProObj[0].p_purity_real_show]}
货号：A241007同义名：
16-Deoxoalisol C
Alisol B is a natural product isolated and purified from the tubers of Alisma plantago-aquatica Linn. for bone disorders by targeting the differentiation of osteoclasts as well as their functions.
Alisol-B, a phyto-steroid from Alisma orientale Juzepczuk, exhibited inhibitory effects on osteoclastogenesis both in vitro and in vivo. Addition of alisol-B to co-cultures of mouse bone marrow cells and primary osteoblasts with 10(-8)M Alisol B caused significant inhibition of osteoclastogenesis. Alisol-B strongly inhibited RANKL-induced osteoclast formation when added during the early stage of cultures, suggesting that alisol-B acts on osteoclast precursors to inhibit RANKL/RANK signaling. In addition, alisol-B suppressed the pit-forming activity and disrupted the actin ring formation of mature osteoclasts[3]. Alisol B-treated cells displayed an increase of autophagic flux and formation of autophagosomes, leading to cell cycle arrest at the G(1) phase and cell death. Alisol B induced calcium mobilization from internal stores, leading to autophagy through the activation of the CaMKK-AMPK-mammalian target of rapamycin pathway. Moreover, the disruption of calcium homeostasis induces endoplasmic reticulum stress and unfolded protein responses in alisol B-treated cells, leading to apoptotic cell death[4].
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