Cardamonin can supress numerous signaling pathways including TNF-α, COX-2, Wnt/β-catenin and NF-κB, suppresses melanogenesis by inhibition of Wnt/β-catenin signaling, and possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation. It is a natural product isolated and purified from the seeds of Alpinia katsumadai Hayata.
Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells[3]. In vivo, cardamonin (25 mg/kg once every other day from days 13) enhances chemotherapy efficacy[4].
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