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(E)-Cardamonin

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Chemical Structure| 19309-14-9 同义名 : 小豆蔻素 ;(E)-Cardamomin;(E)-Alpinetin chalcone;Cardamonin;cardamomin;Alpinetin chalcone
CAS号 : 19309-14-9
货号 : A114338
分子式 : C16H14O4
纯度 : 99%
分子量 : 270.28
MDL号 : -
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(111 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells[3]. In vivo, cardamonin (25 mg/kg once every other day from days 13) enhances chemotherapy efficacy[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.50mL

3.70mL

1.85mL

37.00mL

7.40mL

3.70mL
参考文献

[1]Jaiswal S, Sharma A, et al. Gender-related pharmacokinetics and bioavailability of a novel anticancer chalcone, cardamonin, in rats determined by liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 1;986-987:23-30.

[2]Kim EJ, Kim HJ, et al. Cardamonin Suppresses TGF-β1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression. Biomol Ther (Seoul). 2015 Mar;23(2):141-8.

[3]Li Y, Qin Y, Yang C, Zhang H, Li Y, Wu B, Huang J, Zhou X, Huang B, Yang K, Wu G. Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma. Cell Death Dis. 2017 Aug 31;8(8):e3024. doi: 10.1038/cddis.2017.407. Retraction in: Cell Death Dis. 2019 Mar 27;10(4):289. PMID: 29048425; PMCID: PMC5596588.

[4]Jia D, Tan Y, Liu H, Ooi S, Li L, Wright K, Bennett S, Addison CL, Wang L. Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo. Oncotarget. 2016 Jan 5;7(1):771-85. doi: 10.18632/oncotarget.5819. PMID: 26506421; PMCID: PMC4808032.