(-)-Epigallocatechin Gallate | EGCG;Epigallocatechol Gallate;EGCG-Epigallocatechin Gallate) | (-)-表没食子儿茶素没食子酸酯 | Plant Standard | Telomerase | DNA Methyltransferase

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(-)-表没食子儿茶素没食子酸酯 /(-)-Epigallocatechin Gallate 99%

货号：A110153 同义名： (-)-表没食子儿茶素没食子酸酯 / EGCG;Epigallocatechol Gallate

(-)-Epigallocatechin Gallate 是绿茶中的主要多酚，能抑制细胞增殖并诱导细胞凋亡，抑制谷氨酸脱氢酶 1/2 (GDH1/2, GLUD1/2) 活性，具有抗癌、抗氧化和抗炎特性。

(-)-Epigallocatechin Gallate 化学结构
CAS号：989-51-5

(-)-Epigallocatechin Gallate 3D分子结构
CAS号：989-51-5

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(-)-Epigallocatechin Gallate 纯度/质量文件产品仅供科研

货号：A110153 标准纯度： 99% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

端粒酶亚型比较
DNA甲基转移酶亚型比较

产品名称	Telomerase ↓ ↑	纯度
4',7-Dimethoxyisoflavone	✔	98%+
BIBR 1532	+++ Telomerase, IC50: 100 nM	99%+
Costunolide	++ Telomerase (MDA-MB-231), IC50: 65 μM Telomerase (MCF-7), IC50: 90 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	DNA Methyltransferase ↓ ↑	纯度
6-Thioguanine	✔	99%+
Zebularine	✔	99%+
Procainamide hydrochloride	✔	99%
5-Azacytidine	✔	99%+
Decitabine	✔	99%
SGI-1027	++ DNMT1, IC50: 6 μM DNMT3A, IC50: 7.5 μM	99%+
RG108	+++ DNA methyltransferase, IC50: 115 nM	99%+
Guadecitabine sodium	✔	99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(-)-Epigallocatechin Gallate 生物活性

靶点

EGFR/ErbB1

描述

Epigallocatechin-3-gallate (EGCG), also termed Epigallocatechol Gallate, the most abundant and most biologically active catechin from green tea, is a potential therapeutic agent for preventing neurodegenerative, inflammatory diseases and cancer. In vitro EGCG supplementation dose-dependently reduced neutrophil migration induced by chemokine interleukin (IL)-8 with an IC₅₀ lower than 1 mM and by cytokine-induced neutrophil chemoattractant-1 at a dose of 15 mg/ml or higher^[3]. PC12 cells cultured without serum were administrated with EGCG (0.1 and 1 μM) for 24h which resulted in improved cell morphology and promoted neurite outgrowth, and significant lower cell mortality as compared with serum free group (~40%). There was a gradual increase in neurite length after exposure to EGCG (0.1 and 1 μM); at 4 days of EGCG (1 μM) treatment 40 ± 0.9 and 25.2 ± 2.2% of detected cells exhibited extended neurites, respectively^[4]. EGCG decreased cell viability as concentration- and time-dependently, with IC₅₀ values of 14.17 µM for human breast cancer cell line T47D and 193.10 µM for normal human foreskin fibroblast cell line HFF cells, through down-regulation of PI3K/AKT and telomerase^[5].

(-)-Epigallocatechin Gallate 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
CHO cells		Cytotoxic assay	48 h	Cytotoxicity against CHO cells expressing OATP1B3 haplotype 1 after 48 hrs by fluorescence based CellTiter-Glo assay, IC50=3.2 μM	23327877
HSC-T6 cells		Function assay	48 h	Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay, IC50=9.9 μM	21504848
HSC-T6 cells		Proliferation assay		Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability, IC50=29.8 μM	25322455
human 293T cells	50 μM	Function assay	12 h	Inhibition of DYRK1A in human 293T cells assessed as reduction of GLI1 transcription activity at 50 uM after 12 hrs by dual-luciferase reporter gene assay	22154664

(-)-Epigallocatechin Gallate 参考文献

[1]Pae M, Wu D. Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications. Food Funct. 2013 Sep;4(9):1287-303.

[2]Khan N, Afaq F, et al. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res. 2006 Mar 1;66(5):2500-5.

[3]Donà M, Dell'Aica I, Calabrese F, Benelli R, Morini M, Albini A, Garbisa S. Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis. J Immunol. 2003 Apr 15;170(8):4335-41. doi: 10.4049/jimmunol.170.8.4335. PMID: 12682270.

[4]Reznichenko L, Amit T, Youdim MB, Mandel S. Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth. J Neurochem. 2005 Jun;93(5):1157-67. doi: 10.1111/j.1471-4159.2005.03085.x. PMID: 15934936.

[5]Moradzadeh M, Hosseini A, Erfanian S, Rezaei H. Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase. Pharmacol Rep. 2017 Oct;69(5):924-928. doi: 10.1016/j.pharep.2017.04.008. Epub 2017 Apr 13. PMID: 28646740.

(-)-Epigallocatechin Gallate 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.91mL

2.18mL

1.09mL

21.82mL

4.36mL

2.18mL

(-)-Epigallocatechin Gallate 技术信息

CAS号	989-51-5
分子式	C₂₂H₁₈O₁₁
分子量	458.372

别名	(-)-表没食子儿茶素没食子酸酯 ;EGCG;Epigallocatechol Gallate;EGCG-Epigallocatechin Gallate)
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 30 mg/mL(65.45 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 20 mg/mL(43.63 mM)，配合低频超声助溶

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

CHO cells		Cytotoxic assay	48 h	Cytotoxicity against CHO cells expressing OATP1B3 haplotype 1 after 48 hrs by fluorescence based CellTiter-Glo assay, IC50=3.2 μM	23327877
HSC-T6 cells		Function assay	48 h	Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay, IC50=9.9 μM	21504848
HSC-T6 cells		Proliferation assay		Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability, IC50=29.8 μM	25322455
human 293T cells	50 μM	Function assay	12 h	Inhibition of DYRK1A in human 293T cells assessed as reduction of GLI1 transcription activity at 50 uM after 12 hrs by dual-luciferase reporter gene assay	22154664
human A431 cells		Proliferation assay	48 h	Antiproliferative activity against human A431 cells overexpressing ErbB in serum-free medium assessed as cell viability after 48 hrs by WST-1 assay, EC50=38 μM	24456004
human A431 cells	100 μM	Function assay	12 h	Reduction of clustering of GFP-GPI in lipid rafts of human A431 cells at 100 uM after 12 hrs by confocal microscopic analysis	24456004
human Caco-2 cells	25 μM	Growth inhibition assay	6 days	Growth inhibition of human Caco-2 cells at 25 uM after 6 days	18324763
human HeLa cells		Function assay		Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction followed by compound washout by spin-telomeric repeat amplification protocol, IC50=1.08 μM	22413845
human HepG2 cells		Function assay	24 h	Inhibition of oleic acid-induced triglyceride over-accumulation in human HepG2 cells incubated for 24 hrs relative to untreated control	21824690
human HepG2 cells		Function assay	24 h	Antioxidant activity in human HepG2 cells assessed as reduction of oleic acid-induced ROS generation incubated for 24 hrs by DHCF-DA based fluorimetric assay relative to untreated control	21824690
human HL60 cells		Proliferation assay	3 days	Antiproliferative activity against human HL60 cells after 3 days, IC50=9.4 μM	18693020
human HL60 cells		Function assay	24 h	Induction of 67 kDa laminin receptor expression in human HL60 cells after 24 hrs by flow cytometry analysis	21434603
human Jurkat cells	10-55 μM	Function assay	24 h	Inhibition of TNFalpha-induced NF-kappaB activation in human Jurkat cells at 10 to 55 uM after 24 hrs by electrophoretic mobility shift assay	21080642
human K562 cells		Function assay	24 h	Induction of 67 kDa laminin receptor expression in human K562 cells after 24 hrs by flow cytometry analysis	21434603
human MDA435/LCC6MDR cells	10 μM	Function assay	5 days	Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for paclitaxel at 10 uM after 5 days by CellTiter 96 Aqueous assay, IC50=0.1226 μM	25985195
human MDA-MB-231 cells		Proliferation assay	24 h	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	22459208
human MDA-MB-231 cells		Proliferation assay	24 h	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	22459208
human PC3 cells	10-100 μM	Proliferation assay	48 h	Antiproliferative activity against human PC3 cells at 10 to 100 uM after 48 hrs by hemocytometric cell counting method	23867167
human Raji cells	10 μM	Growth inhibition assay	48 h	Growth inhibition against human Raji cells assessed as cell viability at 10 uM after 48 hrs by trypan blue based microscopic analysis in presence of superoxide dismutase	21434603
human SKBR3 cells	200μM	Function assay	30 mins	Downregulation of ErbB2 protein expression in human SKBR3 cells in serum free medium at 200 uM after 30 mins by immunofluorescence staining-based confocal microscopic analysis	24456004
human U937 cells		Function assay		Inhibition of telomerase in human U937 cells, IC50=1 μM	22413845
MDCK cells		Function assay	4 days	Antiviral activity against influenza A virus (A/swine/OH/511445/2007(H1N1)) Oh7 infected in MDCK cells assessed as inhibition of viral replication after 4 days by quantitative RT-PCR, ED50=8.3 μM	22115591
mouse 3T3 cells	1-20 μM	Function assay	12 h	Antimigratory activity against Swiss albino mouse 3T3 cells assessed as increase of cell numbers at 1 to 20 uM after 12 hrs by by scratch-wound assay	21080642
mouse 3T3-L1 cells		Function assay		Inhibition of G6PD-mediated NADPH production in mouse 3T3-L1 cells, IC50=25 μM	18313308
mouse RAW264.7 cells		Function assay	5 days	Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as decrease in TRAP-positive multi-nucleated cells after 5 days, IC50=29.8 μM	21456521
Sf9 cells		Function assay		Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintillation counting method, IC50=0.5 μM	25406944
SH-SY5Y cells		Function assay		Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release, EC50=0.03987 μM	19138859

(-)-表没食子儿茶素没食子酸酯 /(-)-Epigallocatechin Gallate 99%

(-)-Epigallocatechin Gallate 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

(-)-Epigallocatechin Gallate 质控信息

(-)-Epigallocatechin Gallate 生物活性

(-)-Epigallocatechin Gallate 细胞研究

(-)-Epigallocatechin Gallate 参考文献

(-)-Epigallocatechin Gallate 实验方案

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(-)-Epigallocatechin Gallate 技术信息

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