ICA-105574是一种有效的 hERG 通道激活剂，主要通过消除 hERG 通道失活来增强其活性，能够将电流幅度增强超过 10 倍，EC₅₀ 值为 0.5 μM，适用于与心脏电生理和药物安全性相关的研究。

Pinacidil是一种有效的钾通道 (potassium channel) 激活剂，可通过打开K+通道使血管平滑肌超极化，显示出抗高血压作用。此外，Pinacidil 显著改善再灌注后的心脏功能，并具有直接的心脏保护作用。

Linopirdine 2HCl is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.

Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.

SKA 31 is an activator of KCa3.1 and KCa2 channels with EC50 of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.

Azimilide is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.

GAL-021 a new intravenous Potassium Channel KCa1.1 blocker.

OR-1896 是 Levosimendan 的活性代谢产物，作为一种高选择性的磷酸二酯酶 (PDE III) 抑制剂，同时是一种强效血管扩张剂，能够打开 ATP 敏感的 K⁺ 通道，并具有钙敏感作用，可减轻心肌细胞凋亡、心脏重塑和心肌炎症。

VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV.

VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1.

NS-1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.

GSK369796 is an anti-malaria drug candidate.

ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM.

NS 11021 is a potent and specific KCa1.1 channels activator.

VU0071063 can activate native Kir6.2/SUR1 channels, thereby inhibiting glucose-stimulated calcium entry in isolated mouse pancreatic β cells.

CLP257 是一种选择性的 K+-Cl− 共转运体 KCC2 激活剂，EC50 值为 616 nM。CLP257 对 NKCC1、GABAA 受体、KCC1、KCC3 和 KCC4 无活性。

Flindokalner, also known BMS-204352, is a neuroprotectant. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors.

TAK-438 Free Base is a blocker of potassium-competitive proton pump that reversibly inhibits H+/K+ ATPase with IC50 of 17 nM at pH 6.5 while do not affect on Na+/K+ ATPase activity. It has been used to treatment of erosive esophagitis and gastroduodenal ulcer.

Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2+-dependent K+ channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation.

Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents.