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Oxytocin是一种多效性神经垂体激素,参与分娩、哺乳和亲社会行为的调节。它具有抗炎、抗氧化和保护作用,尤其在面对创伤或逆境时。Oxytocin 可用作研究压力应对和神经生物学的模型分子。
LIT-001是首个非肽类催产素受体 (OT-R) 激动剂,EC50为55 nM,Ki值为226 nM。
Cligosiban是一种口服有效的高选择性催产素受体拮抗剂,Ki为9.5 nM,用于抑制啮齿动物的生理性射精,具有良好的药代动力学特性。
Oxytocin acetate是一种哺乳动物神经垂体激素,通过特异性的、高亲和力的催产素受体介导其作用,是催产素受体的配体。
Atosiban acetate是一种宫缩抑制剂,可通过抑制催产素介导的肌层细胞钙离子释放,达到快速抑制子宫收缩的效果,常用于治疗早产。
Atosiban是一种九肽类加压素/催产素受体拮抗剂,可用作宫缩抑制剂,用于自发性早产的研究和治疗。
Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth and an agonist at peripheral oxytocin receptors.
Lysipressin is an antidiuretic hormone that havs been found in pigs and some marsupial families. It can induce contraction of the rabbit urinary bladder smooth muscle.
L-368,899 HCl is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.
OT-R antagonist 1 is a potent and selective nonpeptide low molecular weight OT-R antagonist.
SHR1653 is a highly potent oxytocin receptor antagonist with excellent blood-brain barrier penetration. It might be beneficial for the treatment of CNS-related premature ejaculation.
OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
Retosiban is an oral active, potent and selective, sub-nanomolar (Ki = 0.65 nM) oxytocin receptor antagonist with > 1400-fold selectivity over the related vasopressin receptors. Retosiban inhibits the procontractile effect of stretch on human myometrium and prevent stretch-induced stimulation of human myometrial contractility.
GSK 557296 is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor.
OT-R antagonist 2 is a nonpeptide low molecular weight OT-R antagonist.
OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1.
Tags: OXTR | G蛋白偶联受体/G蛋白 | GPCR/G Protein | OXTR 相关产品
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