货号:A601702 同义名: RW22164 acetate;RWJ22164 acetate
Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
产品名称 | Vasopressin receptor 1 ↓ ↑ | Vasopressin receptor 2 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||||
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Conivaptan hydrochloride | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Atosiban acetate (also known as RW22164 acetate or RWJ22164 acetate), a nonapeptide, functions as a competitive antagonist to vasopressin/oxytocin receptors and is an analog of desamino-oxytocin. It is primarily used as a tocolytic agent for the investigation of spontaneous preterm labor[1]. |
体内研究 | The neuropeptides oxytocin and arginine vasopressin, which only differ by two amino acids, are both posterior pituitary hormones. Atosiban modulates the arginine vasopressin-induced physiological impacts on the cardiovascular and renal systems of the fetus and mother. In experiments involving late-gestation sheep, administering Atosiban for one hour does not result in any fetomaternal cardiovascular modifications[1]. Atosiban also inhibits the activation of neurons expressing oxytocin receptors in the parabrachial nucleus of mice[2]. |
体外研究 | Atosiban prevents the release of IP3 triggered by oxytocin from the myometrial cell membrane, thereby reducing the release and influx of calcium within myometrial cells, and diminishing oxytocin-induced release of PGE and PGF from the decidua[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.95mL 0.19mL 0.09mL |
4.74mL 0.95mL 0.47mL |
9.49mL 1.90mL 0.95mL |
CAS号 | 914453-95-5 |
分子式 | C45H71N11O14S2 |
分子量 | 1054.241 |
别名 | RW22164 acetate;RWJ22164 acetate |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(99.6 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 50 mg/mL(47.43 mM),配合低频超声助溶 |
动物实验配方 |