Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
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HazMat fee for 500 gram (Estimated)
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Atosiban acetate (also known as RW22164 acetate or RWJ22164 acetate), a nonapeptide, functions as a competitive antagonist to vasopressin/oxytocin receptors and is an analog of desamino-oxytocin. It is primarily used as a tocolytic agent for the investigation of spontaneous preterm labor[1].
体内研究
The neuropeptides oxytocin and arginine vasopressin, which only differ by two amino acids, are both posterior pituitary hormones. Atosiban modulates the arginine vasopressin-induced physiological impacts on the cardiovascular and renal systems of the fetus and mother. In experiments involving late-gestation sheep, administering Atosiban for one hour does not result in any fetomaternal cardiovascular modifications[1].
Atosiban also inhibits the activation of neurons expressing oxytocin receptors in the parabrachial nucleus of mice[2].
体外研究
Atosiban prevents the release of IP3 triggered by oxytocin from the myometrial cell membrane, thereby reducing the release and influx of calcium within myometrial cells, and diminishing oxytocin-induced release of PGE and PGF from the decidua[1].
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