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加压素受体
OXTR
/ Atosiban

阿托西班 /Atosiban {[allProObj[0].p_purity_real_show]}

货号：A600380 同义名： RW22164;RWJ22164

Atosiban is competitive antagonist of vasopressin and oxytocin receptors. It is a nonapeptide and the analogue of desamino-oxytocin.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Atosiban 化学结构 CAS号：90779-69-4
Atosiban 化学结构
CAS号：90779-69-4
Atosiban 3D分子结构
CAS号：90779-69-4
Atosiban 化学结构 CAS号：90779-69-4
Atosiban 3D分子结构 CAS号：90779-69-4
规格 价格 会员价 库存 数量
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Atosiban 纯度/质量文件 产品仅供科研

货号：A600380 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Vasopressin receptor 1 ↓ Vasopressin receptor 2 ↓ 其他靶点 纯度
Conivaptan hydrochloride ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Atosiban 生物活性

描述 Atosiban is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua[3]. Atosiban resulted in fewer maternal side-effects than nifedipine, with no difference in pregnancy prolongation[4].

Atosiban 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00599898 Labor, Premature Phase 4 Completed - Israel ... 展开 >> HaEmek Medical Center Afula, Israel, 18100 收起 <<
NCT01796522 Preterm Delivery. Phase 3 Withdrawn(have been published ... 展开 >>new studies that it showed the ineffectiveness of the treatments proposed in this study.) 收起 << May 2013 Spain ... 展开 >> Hospital Universitari y Politécnic La Fe Valencia, Spain, 46026 收起 <<
NCT02292784 Obstetric Labour, Premature Phase 2 Phase 3 Recruiting July 29, 2022 -

Atosiban 参考文献

[1]Sanu O, Lamont RF. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9.

[2]Akerlund M, Carlsson AM, et al. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand. 1985;64(6):499-504.

[3]Sanu O, Lamont RF. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9

[4]Ali AA, Sayed AK, El Sherif L, Loutfi GO, Ahmed AMM, Mohamed HB, Anwar AT, Taha AS, Yahia RM, Elgebaly A, Abdel-Daim MM. Systematic review and meta-analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor. Int J Gynaecol Obstet. 2019 May;145(2):139-148

Atosiban 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.01mL

0.20mL

0.10mL

5.03mL

1.01mL

0.50mL

10.06mL

2.01mL

1.01mL

Atosiban 技术信息

CAS号90779-69-4
分子式C43H67N11O12S2
分子量 994.19
别名 RW22164;RWJ22164;Tractocile;ORF 22164;Antocin;Atosiban Acetate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 16 mg/mL(16.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(15.09 mM)，配合低频超声助溶
动物实验配方

Tags: Atosiban | RW22164;RWJ22164;Tractocile;ORF 22164;Antocin;Atosiban Acetate | Vasopressin Receptor | OXTR | AmBeed-信号通路专用抑制剂 | Atosiban 纯度/质量文件 | Atosiban 亚型比较 | Atosiban 生物活性 | Atosiban 临床数据 | Atosiban 参考文献 | Atosiban 实验方案 | Atosiban 技术信息

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