Oxytocin acetate is a mammalian neurohypophysial hormone and its actions are mediated by specific, high-affinity oxytocin receptors and ligand of oxytocin receptor.
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Oxytocin (α-Hypophamine) acetate, a multifunctional hypothalamic peptide, is recognized for its critical role in enhancing childbirth, milk production, and positive social interactions. It also serves as a molecule that helps manage stress with its anti-inflammatory, antioxidant, and protective properties, particularly under challenging or traumatic conditions[1].[2].
体内研究
In the context of the LMA (Learned Motor Activity) task, the core body temperature of rats experiences a slight reduction. A single dose of Oxytocin acetate through subcutaneous injection (ranging from 0.1 mg/kg to 0.3 mg/kg) induces a notably higher level of hypothermia at 0.3 mg/kg compared to saline or lower oxytocin doses. Specifically, Oxytocin at 0.3 mg/kg significantly reduces temperature more than the vehicle from 15 to 60 minutes after injection, while a dose of 0.1 mg/kg only mildly lowers temperature at the 30-minute mark[1].
With a dosage of 0.1 mg/kg, Oxytocin acetate leads to a noticeable increase in body and ano-genital sniffing behaviors compared to saline-treated controls. Furthermore, it extends the duration of social engagement to 71.6±4.3 seconds, in contrast to vehicle-treated subjects, who spend 56.9±4.1 seconds[1].
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