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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / OXTR / Oxytocin

Oxytocin {[allProObj[0].p_purity_real_show]}

货号：A387421 同义名： α-Hypophamine;Oxytocic hormone Ambeed 开学季，买赠积分，赢豪礼

Oxytocin is a mammalian neurohypophysial hormone which stimulates uterine contraction and lactation.

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Oxytocin 化学结构 CAS号：50-56-6
Oxytocin 化学结构
CAS号：50-56-6
Oxytocin 3D分子结构
CAS号：50-56-6
Oxytocin 化学结构 CAS号：50-56-6
Oxytocin 3D分子结构 CAS号：50-56-6
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Oxytocin 纯度/质量文件 产品仅供科研

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Oxytocin 生物活性

描述 The OXTR (oxytocin receptor), a 7-transmembrane G protein-coupled receptor capable of binding to either Gαi or Gαq proteins, activates a set of signaling cascades, such as the MAPK, PKC, PLC, or CaMK pathways, which converge on transcription factors like CREB or MEF-2[3]. Oxytocin has been regulating reproductive and social behaviors for more than 500 million years. In all mammals, oxytocin is the hormone indispensable for milk-ejection during nursing (maternal milk provision to offspring), a process that is crucial for successful mammalian parental care. In laboratory mice, a remarkable transcriptional activation occurs during parental behavior within the anterior commissural nucleus (AC), the largest magnocellular oxytocin cell population within the medial preoptic area[4]. Oxytocin has also been linked to many domains within the realm of "social cognition." For example, oxytocin affects trusting behavior, cooperation, as well as the perception and processing of facial expressions. Furthermore, oxytocin increases empathy and seems to exert differential effects on in-group versus out-group preferences[5].

Oxytocin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03742531 Oxytocin Indu... 展开 >>ction of Labor 收起 << Phase 2 Recruiting January 1, 2019 Turkey ... 展开 >> Zeynep Kamil Education and Research Hospital Recruiting Istanbul, Turkey Contact: ahmet eser    905067136880    hicoice@yahoo.com 收起 <<
NCT02647268 Postpartum Hemorrhage Not Applicable Completed - Canada, Ontario ... 展开 >> Mount Sinai Hospital Toronto, Ontario, Canada, M5G1X5 收起 <<
NCT03640156 Autism Spectrum Disorder Phase 3 Recruiting December 2019 Belgium ... 展开 >> Katholieke Universiteit Leuven Recruiting Leuven, Belgium, 3000 Principal Investigator: Kaat Alaerts, PhD 收起 <<

Oxytocin 参考文献

[1]Gao S, Becker B, et al. Oxytocin, the peptide that bonds the sexes also divides them. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7650-4.

[2]Granat M. Oxytocin contraindicated in presence of uterine scar. Lancet. 1976 Dec 25;2(8000):1411.

[3]The Oxytocin Receptor: From Intracellular Signaling to Behavior

[4]Oxytocin and Parental Behaviors

[5]Oxytocin and Social Cognition

Oxytocin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.99mL

0.20mL

0.10mL

4.96mL

0.99mL

0.50mL

9.93mL

1.99mL

0.99mL

Oxytocin 技术信息

CAS号50-56-6
分子式C43H66N12O12S2
分子量 1007.187
别名 α-Hypophamine;Oxytocic hormone;Syntocinon
运输蓝冰
存储条件

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(104.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Oxytocin | α-Hypophamine;Oxytocic hormone;Syntocinon | OXTR | AmBeed-信号通路专用抑制剂 | Oxytocin 纯度/质量文件 | Oxytocin 生物活性 | Oxytocin 临床数据 | Oxytocin 参考文献 | Oxytocin 实验方案 | Oxytocin 技术信息

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