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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / OXTR / Oxytocin/催产素

Oxytocin/催产素 {[allProObj[0].p_purity_real_show]}

货号：A387421 同义名： 缩宫素 / α-Hypophamine; Oxytocic hormone

Oxytocin是一种多效性神经垂体激素，参与分娩、哺乳和亲社会行为的调节。它具有抗炎、抗氧化和保护作用，尤其在面对创伤或逆境时。Oxytocin 可用作研究压力应对和神经生物学的模型分子。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Oxytocin/催产素 化学结构 CAS号：50-56-6
Oxytocin/催产素 化学结构
CAS号：50-56-6
Oxytocin/催产素 3D分子结构
CAS号：50-56-6
Oxytocin/催产素 化学结构 CAS号：50-56-6
Oxytocin/催产素 3D分子结构 CAS号：50-56-6
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Oxytocin/催产素 纯度/质量文件 产品仅供科研

货号：A387421 标准纯度： {[allProObj[0].p_purity_real_show]}
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Oxytocin/催产素 生物活性

描述 The OXTR (oxytocin receptor), a 7-transmembrane G protein-coupled receptor capable of binding to either Gαi or Gαq proteins, activates a set of signaling cascades, such as the MAPK, PKC, PLC, or CaMK pathways, which converge on transcription factors like CREB or MEF-2[3]. Oxytocin has been regulating reproductive and social behaviors for more than 500 million years. In all mammals, oxytocin is the hormone indispensable for milk-ejection during nursing (maternal milk provision to offspring), a process that is crucial for successful mammalian parental care. In laboratory mice, a remarkable transcriptional activation occurs during parental behavior within the anterior commissural nucleus (AC), the largest magnocellular oxytocin cell population within the medial preoptic area[4]. Oxytocin has also been linked to many domains within the realm of "social cognition." For example, oxytocin affects trusting behavior, cooperation, as well as the perception and processing of facial expressions. Furthermore, oxytocin increases empathy and seems to exert differential effects on in-group versus out-group preferences[5].

Oxytocin/催产素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03742531 Oxytocin Indu... 展开 >>ction of Labor 收起 << Phase 2 Recruiting January 1, 2019 Turkey ... 展开 >> Zeynep Kamil Education and Research Hospital Recruiting Istanbul, Turkey Contact: ahmet eser    905067136880    hicoice@yahoo.com 收起 <<
NCT02647268 Postpartum Hemorrhage Not Applicable Completed - Canada, Ontario ... 展开 >> Mount Sinai Hospital Toronto, Ontario, Canada, M5G1X5 收起 <<
NCT03640156 Autism Spectrum Disorder Phase 3 Recruiting December 2019 Belgium ... 展开 >> Katholieke Universiteit Leuven Recruiting Leuven, Belgium, 3000 Principal Investigator: Kaat Alaerts, PhD 收起 <<

Oxytocin/催产素 参考文献

[1]Gao S, Becker B, et al. Oxytocin, the peptide that bonds the sexes also divides them. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7650-4.

[2]Granat M. Oxytocin contraindicated in presence of uterine scar. Lancet. 1976 Dec 25;2(8000):1411.

[3]The Oxytocin Receptor: From Intracellular Signaling to Behavior

[4]Oxytocin and Parental Behaviors

[5]Oxytocin and Social Cognition

Oxytocin/催产素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.99mL

0.20mL

0.10mL

4.96mL

0.99mL

0.50mL

9.93mL

1.99mL

0.99mL

Oxytocin/催产素 技术信息

CAS号50-56-6
分子式C43H66N12O12S2
分子量 1007.19
SMILES Code CC[C@@H]([C@@H]1NC([C@@H](NC([C@H](CSSC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CC(C)C)=O)=O)NC([C@@H](NC([C@@H](NC1=O)CCC(N)=O)=O)CC(N)=O)=O)N)=O)CC3=CC=C(O)C=C3)=O)C
MDL No. MFCD00076731
别名 缩宫素 ;α-Hypophamine; Oxytocic hormone; Syntocinon
运输蓝冰
InChI Key XNOPRXBHLZRZKH-DSZYJQQASA-N
Pubchem ID 439302
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(104.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

Tags: Oxytocin | α-Hypophamine;Oxytocic hormone;Syntocinon | OXTR | AmBeed-信号通路专用抑制剂 | Oxytocin/催产素 纯度/质量文件 | Oxytocin/催产素 生物活性 | Oxytocin/催产素 临床数据 | Oxytocin/催产素 参考文献 | Oxytocin/催产素 实验方案 | Oxytocin/催产素 技术信息

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