Tofacitinib citrate是一种口服有效的JAK1/2/3抑制剂，其IC50值分别为1、20和112 nM。它还具有抗细菌、抗真菌和抗病毒特性。

AT9283 is a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl (T315I), JAK2 and JAK3, Aurora A and Aurora B, respectively.

Momelotinib（CYT387）是一种ATP竞争性JAK1/JAK2抑制剂，其IC50值分别为11 nM和18 nM，对JAK3的活性显著较低。

Tofacitinib是一种口服可用的 JAK3/2/1 抑制剂，其 IC50 值分别为 1 nM、20 nM 和 112 nM。

TG 101209 is a potent and selective JAK2 inhibitor with IC50 of 6 nM, also inhibits Flt3 and RET with IC50 values of 25 nM and 17 nM, respectively.

Gandotinib (LY2784544) 是一种强效的 JAK2 抑制剂，其 IC50 为 3 nM。Gandotinib (LY2784544) 还抑制 FLT3、FLT4、FGFR2、TYK2 和 TRKB，其 IC50 值分别为 4 nM、25 nM、32 nM、44 nM 和 95 nM。

Pacritinib (SB1518) 是一种强效抑制野生型 JAK2 (IC50 = 23 nM) 和 JAK2V617F 突变体 (IC50 = 19 nM) 的抑制剂，同时也抑制 FLT3 (IC50 = 22 nM) 及其突变体 FLT3D835Y (IC50 = 6 nM)。

WHI-P154 is a specific inhibitor of JAK3 with IC50 value of 1.8 μM, almost shows no activity against JAK1 or JAK2.

XL019 is a selective and potent JAK2 inhibitor with IC50 value of 2.2 nM, with less potency to JAK1, JAK3, FLT3 and PDGFRβ with IC50 values of 134.3 nM, 214.2 nM, 139.7 nM and 125.4 nM, respectively.

Oclacitinib Fumarate is a potent JAK inhibitor with IC50 value ranging in 10-99 nM for JAK family members, most potent against JAK1 with IC50 value of 10 nM.

Decernotinib is a selective JAK3 inhibitor with Ki value of 2.5nM, with >4-fold selectivity over JAK1, JAK2, and TYK2 with Ki values of 11nM, 13nM and 13nM, respectively.

Cerdulatinib (PRT062070) 是一种有效且选择性的 Tyk2 抑制剂，IC50 为 0.5 nM。它是 JAK 和 SYK 的双重抑制剂，对 JAK1、JAK2、JAK3 和 SYK 的 IC50 值分别为 12、6、8 和 32 nM。

Filgotinib is a selective JAK1/2 inhibitor with IC50 values of 10/28nM, with less potency against JAK3 and TYK2 with IC50 values of 810 nM and 116 nM, respectively.

NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM and > 20-fold selectivity towards JAK1, JAK3 and TYK2.

ZM39923 HCl is a potent and selective JAK3 inhibitor with pIC50 value of 7.1, as well as inhibits EGFR, JAK1 and CDK4 with pIC50 values of 5.6, 4.4, and < 5.0.

FM381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909 at the gatekeeper position +7 in JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

BMS-911543 is a selective ATP-competitive JAK2 inhibitor with IC50 value of 1.1 nM, with much less potency against JAK1, JAK3 and TYK2 with IC50 values of 360nM, 75 nM and 66nM.