JIB-04是一种广泛选择性Jumonji组蛋白去甲基酶抑制剂，对JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC50分别为230 nM、340 nM、855 nM、445 nM、435 nM、1100 nM和290 nM。

CPI-455 is a selective inhibitor of KDM5 demethylases and can reduce survival of drug-tolerant cancer cells.

(Z)-JIB-04是 JIB-04 的 Z 异构体，具有在某些表观遗传学研究中的潜力。它在细胞信号传导调节方面有应用价值，但在某些情况下可能表现出较低的活性。

IOX1 is the broad-spectrum inhibitor of 2OG oxygenases and its IC50 for KDM4A/KDM3A and KDM4C/KDM6B/KDM2A/KDM4E are 0.6/0.1 μM and 0.6 μM/1.6 μM/1.8 μM/2.3 μM.

GSK467 is a selective KDM5 inhibitor with Ki of 10 nM. It has no measurable inhibitory effects toward other JmJ family members.