Miglitol is a desoxynojirimycin-derived inhibitor of alpha-glucosidase with antihyperglycemic activity.

Voglibose, an N-substituted derivative of valiolamine, can inhibit α-glucosidase and be used to treat hyperglycemia and its concomitant diseases.

MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.

Acarbose is an intestinal alpha-glucosidase inhibitor and can be used to treat type 2 diebetes.

Linagliptin, a purine and quinazoline derivative, can inhibit DPP-4 with IC50 of 1 nM. It functions as an incretin and is used as a hypoglycemic agents in the treatment of type 2 diabetes mellitus.

Omarigliptin, also called MA-3102, is an selective inhibitor of DPP-4 with IC50 of 1.6 nM and Ki of 0.8 nM. Its selectivity is higher than other 168 proteasomes.

Alogliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50 of 6.9 nM that exhibits greater selective than DPP-2, DPP-8 and DPP-9.

Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

Teneligliptin Hydrobromide is a DPP4 inhibitor with IC50 value of <1 nM. It is commonly used as an add on treatment when meformin is not achieving the expected glycemic goals.

Glibenclamide (Glyburide)是一种口服活性ATP敏感的K+通道（KATP）抑制剂，用于糖尿病和肥胖研究。它抑制P-糖蛋白，直接结合并阻断KATP的SUR1亚基，抑制囊性纤维化跨膜传导调节蛋白（CFTR），通过改变膜离子通透性干扰线粒体生物能量学，并能诱导自噬。

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.

Irbesartan is a selective and competitive nonpeptide angiotensin II antagonist with antihypertensive activity.

Aminoguanidine HCl is a selective and irreversible iNOS inhibitor.

Sitagliptin Phosphate Monohydrate is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts.

Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 3.0 nM in pancreatic β-cells with fewer cardiac actions. It is used in the treatment of type 2 diabetes mellitus.

Vildagliptin is an inhibitor of DPP-4 with IC50 of 2.3 nM that is used in the treatment of type 2 diabetes mellitus.

Gliclazide is a blocker of pancreatic β-cell ATP-sensitive potassium channels with IC50 of 184 nM in murine. It belongs to the sulfonylurea class of insulin secretagoguesIt. Gliclazide is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

Pioglitazone HCl是一种强效且选择性的PPARγ激动剂，对人类和小鼠PPARγ的EC50值分别为0.93 μM和0.99 μM。

Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.

OLDA is an agonist of endogenous vanilloid TRPV1 (VR1) receptor with EC50 of 36 nM and low affinity for rCB1 receptors (Ki = 1.6 μM).