α-glucosidases are enzymes responsible for the metabolism of complex carbohydrates into absorbable monosaccharide units. However, hyperglycemia causes a number of abnormalities which contribute to the development of long-term complications of diabetes. Acarbose, an anti-diabetic drug, is an intestinal α-glucosidase inhibitor[3]. In TNF-α pre-treated A7r5 cells, acarbose (1, 2, and 3 μM) dose-dependently decreased β-galactosidase, Ras expression and increased p-AMPK expression. In HCD (high cholesterol diet)-fed rabbits, the numbers of atherosclerotic plaques in the aortic arch were significantly decreased by acarbose treatment (2.5 and 5.0 mg/kg per day). Further, acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreased the intensity of neointimal IL-6, TNF-α, and iNOS staining, and significantly increased the intensity of neointimal p-AMPK staining. Moreover, acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreased neointimal Ras and β-galactosidase expression in HCD-fed rabbits[4].
United States, Minnesota
... 展开 >>
Minneapolis Medical Research Foundation
Minneapolis, Minnesota, United States, 55404
United States, New York
Columbia University
New York, New York, United States, 10027
United States, North Carolina
Wake Forest University
Winston-Salem, North Carolina, United States, 27106
United States, Ohio
Case Western Reserve University
Cleveland, Ohio, United States, 44106
United States, Tennessee
Veterans Affairs
Memphis, Tennessee, United States, 38104
United States, Washington
University of Washington
Seattle, Washington, United States, 98195
Canada, Ontario
McMaster University
Hamilton, Ontario, Canada 收起 <<
United States, Minnesota
... 展开 >>
Minneapolis Medical Research Foundation
Minneapolis, Minnesota, United States, 55404
United States, New York
Columbia University
New York, New York, United States, 10027
United States, North Carolina
Wake Forest University
Winston-Salem, North Carolina, United States, 27106
United States, Ohio
Case Western Reserve University
Cleveland, Ohio, United States, 44106
United States, Tennessee
Veterans Affairs
Memphis, Tennessee, United States, 38104
United States, Washington
University of Washington
Seattle, Washington, United States, 98195
Canada, Ontario
McMaster University
Hamilton, Ontario, Canada 收起 <<
China, Shanghai
... 展开 >>
Novo Nordisk Investigational Site
Shanghai, Shanghai, China, 200025
Novo Nordisk Investigational Site
Shanghai, Shanghai, China, 200433
China, Sichuan
Novo Nordisk Investigational Site
Chengdu, Sichuan, China, 610041
China
Novo Nordisk Investigational Site
Beijing, China, 100029 收起 <<
China, Shandong
... 展开 >>
Department of Hematology of the 2nd Hospital of Shandong University
Recruiting
Jinan, Shandong, China, 250033
Contact: chengyun zheng, Ph. D +86-531-85875635 chengyun.zheng@ki.se, kdx2002@126.com 收起 <<
China, Beijing
... 展开 >> Beijing Tiantan Hospital
Beijing, Beijing, China, 100050
Xuanwu Hospital Capital Medical University
Beijing, Beijing, China, 100053
Peking Union Medical College Hospital
Beijing, Beijing, China, 100730
China, Chongqing
Southwest Hospital
Chongqing, Chongqing, China, 400038
Daping Hospital
Chongqing, Chongqing, China, 400042
China, Jiangsu
Nanjing General Hospital of Nanjing Military Command
Nanjing, Jiangsu, China, 210002
China, Jilin
Jilin University
Changchun, Jilin, China, 130021
China, Shanghai
Huashan Hospital Fudan University
Shanghai, Shanghai, China, 200040
China, Sichuan
West China Center of Medical Sciences
Chengdu, Sichuan, China, 610041
China, Tianjin
The General Hospital Under Tianjin Medical Sciences University
Tianjin, Tianjin, China, 300052 收起 <<
China
... 展开 >> Research Site
Beijing, China
Research Site
Changchun, China
Research Site
Chuangchun, China
Research Site
Fuzhou, China
Research Site
Guiyang, China
Research Site
Ha'er bin, China
Research Site
Hangzhou, China
Research Site
Hefei, China
Research Site
Jinan, China
Research Site
Nanchang, China
Research Site
Nanjing, China
Research Site
Shanghai, China
Research Site
Shijiazhuang, China
Research Site
Siping, China
Research Site
Tianjin, China
Research Site
Wuxi, China
Research Site
Yueyang, China 收起 <<
France
... 展开 >> Psychiatrie infanto-juvénile - Centre Hospitalier d'Antibes
Antibes, France, 06600
Psychiatrie infanto-juvénile-Pôle femme-mère -enfant
Fréjus, France, 83608
Service de psychiatrie de l'enfant et de l'adolescent
Marseille, France, 13009
Service de psychiatrie de l'enfant et de l'adolescent
Nice, France, 06000 收起 <<
Algeria
... 展开 >>
Many Locations, Algeria
Bosnia and Herzegovina
Many Locations, Bosnia and Herzegovina
Cambodia
Many Locations, Cambodia
China
Many Locations, China
Hong Kong
Many Locations, Hong Kong
India
Many Locations, India
Indonesia
Many Locations, Indonesia
Korea, Republic of
Many Locations, Korea, Republic of
Malaysia
Many Locations, Malaysia
Moldova, Republic of
Many Locations, Moldova, Republic of
Pakistan
Many Locations, Pakistan
Philippines
Many Locations, Philippines
Russian Federation
Many Locations, Russian Federation
Singapore
Many Locations, Singapore
Thailand
Many Locations, Thailand
Vietnam
Many Locations, Vietnam 收起 <<
United States, Minnesota
... 展开 >>
University of Minnesota Medical Center
Recruiting
Minneapolis, Minnesota, United States, 55455
Contact: Jayne Pederson Pederson 612-624-8402 peder059@umn.edu 收起 <<
Taiwan
... 展开 >> Taichung Veterans General Hospital
Recruiting
Taichung, Taiwan
Contact: Wayne H Sheu, MD, PhD 886-4-23592525 ext 3068 whhsheu@vghtc.gov.tw
Principal Investigator: Wayne H Sheu, MD, PhD
Sub-Investigator: I Te Lee, MD, MS 收起 <<
Japan
... 展开 >> Institute of Biomedical Research and Innovation.
Kobe, Hyogo Pref., Japan, 650-0047
Kobe City General Hospital/Institute of Biomedical Research and Innovation
Kobe, Hyogo Pref., Japan, 650-0047
Kawasaki Medical School Hospital
Kurashiki, Okayama, Japan, 701-0192 收起 <<
Korea, Republic of
... 展开 >>
Paik Diabetes Center, Pusan Paik Hospital, College of Medicine, Inje University
Busan, Korea, Republic of, 614-735
Endocrinology and Metabolism, Maryknoll General Hospital
Busan, Korea, Republic of 收起 <<
China
... 展开 >> People's Liberation Army. The Military General Hospital of BeiJing
BeiJing, China, 100020
Peiking University First Hospital
BeiJing, China, 100034
Chinese PLA General Hospital
Beijing, China, 100853
The First Affiliated Hospital, Zhongshan (Sun Yat-sen) University
Guangzhou, China, 510080
The Second Affiliated Hospital, Zhongshan (Sun Yat-sen) University
Guangzhou, China, 510120
Nanfang Hospital, the Affiliated South Hospital of the Southern Medical University
Guangzhou, China, 510515 收起 <<
United States, Oregon
... 展开 >>
Department of Food Science and Technology
Recruiting
Corvallis, Oregon, United States, 97331
Contact: Juyun Lim 541-737-6507 juyun.lim@oregonstate.edu 收起 <<
China
... 展开 >> Research Site
Not yet recruiting
Beijing, China, 100020
Research Site
Not yet recruiting
Beijing, China, 100034
Research Site
Not yet recruiting
Beijing, China, 100730
Research Site
Not yet recruiting
Changsha, China, 410008
Research Site
Not yet recruiting
Changsha, China, 410011
Research Site
Not yet recruiting
Changsha, China, 410013
Research Site
Not yet recruiting
Chengdu, China, 610041
Research Site
Not yet recruiting
Chongqing, China, 400016
Research Site
Not yet recruiting
Guangzhou, China
Research Site
Not yet recruiting
Guiyang, China
Research Site
Recruiting
Hangzhou, China, 310014
Research Site
Not yet recruiting
Hangzhou, China, 310016
Research Site
Not yet recruiting
Hefei, China, 230022
Research Site
Not yet recruiting
Jinan, China, 250012
Research Site
Not yet recruiting
Kunming, China, 650032
Research Site
Not yet recruiting
Nanjing, China, 2100008
Research Site
Not yet recruiting
Nanjing, China, 210029
Research Site
Not yet recruiting
Qingdao, China, 266003
Research Site
Not yet recruiting
Qingdao, China
Research Site
Not yet recruiting
Shanghai, China, 200032
Research Site
Recruiting
Shanghai, China, 200233
Research Site
Recruiting
Shanghai, China, CN-200120
Research Site
Not yet recruiting
Shenyang, China, 100003
Research Site
Not yet recruiting
Shenyang, China, 110001
Research Site
Not yet recruiting
Suzhou, China, 215004
Research Site
Not yet recruiting
Tianjin, China, CN-300070
Research Site
Not yet recruiting
Urumqi, China, 830054
Research Site
Not yet recruiting
Xi'an, China, 710061
Research Site
Not yet recruiting
Xining, China, 810001
Research Site
Not yet recruiting
Yinchuan, China, 750004 收起 <<
The Objectives of the Study is... 展开 >> to Evaluate the Efficacy and Safety of Acarmet (Metformin HCl 500 mg
Plus Acarbose 50 mg Tablets) Thrice Daily Versus Acarbose 50 mg Thrice Daily Over 16 Weeks in
Subjects With Type 2 Diabetes Mellitus. 收起 <<
China, Jiangsu
... 展开 >> The First People's Hospital of Changzhou
Changzhou, Jiangsu, China
The Second People's Hospital of Huai'an
Huai'an, Jiangsu, China
Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Southeast University
Nanjing, Jiangsu, China
Xuzhou Central Hospital
Xuzhou, Jiangsu, China
Yancheng City No.1 People's Hospital
Yancheng, Jiangsu, China
Zhenjiang First People's Hospital
Zhenjiang, Jiangsu, China 收起 <<
China, Anhui
... 展开 >>
Hefei, Anhui, China
Maanshan, Anhui, China
China, Beijing
Beijing, Beijing, China
China, Guangdong
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Taishan, Guangdong, China
China, Hunan
Zhuzhou, Hunan, China
China, Jiangsu
Nanjing, Jiangsu, China
Xuzhou, Jiangsu, China
China, Jilin
Changchun, Jilin, China
Jilin, Jilin, China
China, Liaoning
Shenyang, Liaoning, China
China, Shandong
Qingdao, Shandong, China
China, Shanghai
Shanghai, Shanghai, China
China, Shanxi
Yan An, Shanxi, China
Yanan, Shanxi, China
China, Tianjin
Tianjin, Tianjin, China
China, Zhejiang
Wenzhou, Zhejiang, China 收起 <<
United States, New York
... 展开 >>
Montefiore Medical Center
Recruiting
Bronx, New York, United States, 10461
Contact: Erika F Brutsaert, MD, MPH 866-633-8255
Principal Investigator: Erika F Brutsaert, MD, MPH 收起 <<
Other Specified Hypotension
... 展开 >> Syncope 收起 <<
Phase 2
Recruiting
August 2018
Canada, British Columbia
... 展开 >>
Vancouver Coastal Health Research Institute, VGH Research Pavilion Room 186
Recruiting
Vancouver, British Columbia, Canada, V5Z 1M9
Contact: Boris Feldman 604-875-5115 boris.feldman@vch.ca
Principal Investigator: Kenneth M Madden, MD MSc FRCPC
Sub-Investigator: Graydon Meneilly, MD, FRCPC 收起 <<
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