Saxagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor. DPP-4 inhibition with saxagliptin did not increase or decrease the rate of ischemic events, though the rate of hospitalization for heart failure was increased[3]. Generally, saxagliptin has similar efficacy compared with most oral antidiabetic drugs and may be more effective than acarbose, while having a better safety profile than both acarbose and sulfonylureas[4]. Saxagliptin has a shorter half-life than the other dipeptidyl-peptidase IV inhibitors, so it might be a better choice among drugs in this class for nursing mothers[5]. Dipeptidyl peptidase 4 inhibitors may have a protective effect in diabetic nephropathy. Treatment with saxagliptin improved ACR, even in the normoalbuminuric range, without affecting EGFR[6].
Saxagliptin 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
Caco-2 cells
Function assay
Inhibition of human DPP4 expressed in Caco-2 cells, Ki=0.6 nM
Platelet Aggregation During Ac... 展开 >>ute Myocardial Infarction 收起 <<
Phase 3
Recruiting
December 2019
Brazil
... 展开 >> Heart Institute(InCor)-Acute Coronary Care Unit
Recruiting
São Paulo, SP, Brazil, 01406000
Contact: Paulo R Genestreti, MD 55 11 2661-5058 paulo.gen@ig.com.br
Principal Investigator: Jose C Nicolau, MD,PhD
Sub-Investigator: Paulo R Genestreti, MD 收起 <<
Platelet Aggregation During Ac... 展开 >>ute Myocardial Infarction 收起 <<
Phase 3
Recruiting
December 2019
Brazil
... 展开 >> Heart Institute(InCor)-Acute Coronary Care Unit
Recruiting
São Paulo, SP, Brazil, 01406000
Contact: Paulo R Genestreti, MD 55 11 2661-5058 paulo.gen@ig.com.br
Principal Investigator: Jose C Nicolau, MD,PhD
Sub-Investigator: Paulo R Genestreti, MD 收起 <<
China, Chongqing
... 展开 >>
The Second Affiliated Hospital, Third Military Medical University
Recruiting
Chongqing, Chongqing, China, 400037
Principal Investigator: Hongting Zheng, Ph.D 收起 <<
India
... 展开 >> Research Site
Nellure, Andhra Pradesh, India
Research Site
Vishakhapatnam, Andhra Pradesh, India
Research Site
Guwahati, Assam, India
Research Site
New Delhi, Delhi, India
Research Site
Ahmedabad, Gujarat, India
Research Site
Rajkot, Gujarat, India
Research Site
Vadodara, Gujarat, India
Research Site
Karnal, Haryana, India
Research Site
Yamunanagar, Haryana, India
Research Site
Bangalore, Karnataka, India
Research Site
Trivandrum, Kerala, India
Research Site
Cochin, Kochi, India
Research Site
Bhopal, Madhya Pradesh, India
Research Site
Indore, Madhya Pradesh, India
Research Site
Mumbai, Maharashtra, India
Research Site
Pune, Maharashtra, India
Research Site
Amritsar, Punjab, India
Research Site
Chandigarh, Punjab, India
Research Site
Ludhiana, Punjab, India
Research Site
Jaipur, Rajasthan, India
Research Site
Udaipur, Rajasthan, India
Research Site
Madurai, Tamiladu, India
Research Site
Chennai, Tamilnadu, India
Research Site
Hyderabad, Telangana, India
Research Site
Hyderebad, Telangana, India
Research Site
Allahabad, Uttar Pradesh, India
Research Site
Kanpur, Uttar Pradesh, India
Research Site
Lucknow, Uttar Pradesh, India
Research Site
Noida, Uttar Pradesh, India
Research Site
Kolkata, West Bengal, India
Research Site
new Delhi, India 收起 <<
Terminated(Release of Post Mar... 展开 >>keting Requirement for this study. Terminated November 2013.) 收起 <<
-
United States, Arkansas
... 展开 >>
Osborne Research Center
Little Rock, Arkansas, United States, 72201
United States, California
Axis Clinical Trials
Los Angeles, California, United States, 90036
United States, Kentucky
Kosair Charities Pediatric Clinical Research Unit
Louisville, Kentucky, United States, 40202
United States, Missouri
The Children'S Mercy Hospital And Clinics
Kansas City, Missouri, United States, 64108
United States, Ohio
Promedica Toledo Children'S Hospital
Toledo, Ohio, United States, 43606
Promedica Toledo Childrens Hospital
Toledo, Ohio, United States, 43606
United States, Pennsylvania
Childrens Hospital Of Pittsburgh Of Upmc
Pittsburgh, Pennsylvania, United States, 15224 收起 <<
United States, California
... 展开 >>
Va San Diego Healthcare System
San Diego, California, United States, 92161
United States, Louisiana
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
United States, Texas
Diabetes & Glandular Disease Research Assoc,, Inc.
San Antonio, Texas, United States, 78229 收起 <<
China
... 展开 >> Research Site
Not yet recruiting
Baotou, China, 014016
Research Site
Not yet recruiting
Beijing, China, 100039
Research Site
Not yet recruiting
Beijing, China, 100044
Research Site
Not yet recruiting
Beijing, China, 100101
Research Site
Not yet recruiting
Beijing, China, 100144
Research Site
Not yet recruiting
Beijing, China, 101199
Research Site
Not yet recruiting
Beijing, China, 101200
Research Site
Not yet recruiting
Changchun, China, 130021
Research Site
Not yet recruiting
Chenzhou, China
Research Site
Withdrawn
Chongqing, China, 400014
Research Site
Not yet recruiting
Fuzhou, China, 350025
Research Site
Withdrawn
Guangzhou, China, 510000
Research Site
Withdrawn
Guangzhou, China, 510080
Research Site
Not yet recruiting
Guangzhou, China, 510515
Research Site
Not yet recruiting
Haerbin, China, 150001
Research Site
Not yet recruiting
Hefei, China, 230001
Research Site
Not yet recruiting
Hefei, China
Research Site
Not yet recruiting
Hengyang, China, CN-421001
Research Site
Not yet recruiting
Hohhot, China, 010017
Research Site
Not yet recruiting
Huizhou, China, 516001
Research Site
Not yet recruiting
Jinan, China, 250001
Research Site
Withdrawn
Jinzhou, China, 121004
Research Site
Withdrawn
Nanchang, China, 330006
Research Site
Not yet recruiting
Nanjing, China, 210012
Research Site
Not yet recruiting
Nanjing, China, 210029
Research Site
Not yet recruiting
Nantong, China, 226001
Research Site
Not yet recruiting
Qingdao, China, 266003
Research Site
Not yet recruiting
Shanghai, China, 200240
Research Site
Not yet recruiting
Shantou, China, 515065
Research Site
Not yet recruiting
Shengyang, China, 110004
Research Site
Not yet recruiting
Tangshan, China
Research Site
Not yet recruiting
Tianjin, China, 300211
Research Site
Not yet recruiting
Wuhan, China, 430033
Research Site
Not yet recruiting
Wuhan, China, CN-430022
Research Site
Not yet recruiting
Wulumuqi, China, 830054
Research Site
Not yet recruiting
Xian, China, 710061
Research Site
Withdrawn
Xining, China, 810001
Research Site
Not yet recruiting
Yancheng, China, 224005
Research Site
Withdrawn
Yinchuan, China, 750004
Research Site
Not yet recruiting
Yueyang, China, 414000
Research Site
Not yet recruiting
Zhuzhou, China, 412007
Thailand
Research Site
Not yet recruiting
Bangkok, Thailand, 10400
Vietnam
Research Site
Not yet recruiting
Ho Chi Minh, Vietnam, 10000
Research Site
Not yet recruiting
Ho Chi Minh, Vietnam 收起 <<
Terminated(Inability to recrui... 展开 >>t adequate number of patients within the specified time period.) 收起 <<
-
Philippines
... 展开 >> Research Site
Batangas City, Batangas, Philippines
Research Site
Cebu City, Cebu, Philippines
Research Site
Davao City, Davao, Philippines
Research Site
Iloilo City, Iloilo, Philippines
Research Site
Las Pinas City, Manila, Philippines
Research Site
Makati, Manila, Philippines
Research Site
Pasig, Manila, Philippines
Research Site
Quezon City, Manila, Philippines
Research Site
Mabalacat, Pampanga, Philippines
Research Site
Manila, Philippines 收起 <<
Diabetes Mellitus Type 2
... 展开 >> Severe Hyperglycemia - Blood Glucose Level >300mg/dl. 收起 <<
Phase 4
Unknown
December 2012
United States, Illinois
... 展开 >>
John Stroger Hospital of Cook County
Not yet recruiting
Chicago, Illinois, United States, 60612
Contact: Ambika Babu, M.D. 312-864-0543 Ambika_Babu@rush.edu
Contact: Leon Fogelfeld, M.D. 312-864-0539 lfogelfe@cchil.org
Principal Investigator: Ambika Babu, M.D.
John Stroger Hospital of Cook County
Recruiting
Chicago, Illinois, United States, 60612
Contact: Ambika Babu, M.D. 312-864-0543 aamblee@hotmail.com
Contact: Leon Fogelfeld, M.D. 312-864-0539 lfogelfe@cchil.org
Principal Investigator: Ambika Babu, M.D. 收起 <<
United States, Arizona
... 展开 >>
Dedicated Phase I, Inc.
Phoenix, Arizona, United States, 85013
United States, California
Pacific Sleep Medicine Services (Avastra Clinical Trials)
Redlands, California, United States, 92373
Orange County Research Center
Tustin, California, United States, 92780
United States, Florida
Clinical Research Of South Florida
Coral Gables, Florida, United States, 33134
Palm Springs Research Institute
Hialeah, Florida, United States, 33012
Healthcare Clinical Data, Inc.
North Miami, Florida, United States, 33161
United States, Georgia
River Birch Research Alliance, Llc
Blue Ridge, Georgia, United States, 30513
United States, Michigan
Jasper Clinic, Inc.
Kalamazoo, Michigan, United States, 49007
United States, New York
Clinilabs, Inc.
New York, New York, United States, 10019
United States, Ohio
Medpace Clinical Pharmacology Unit
Cincinnati, Ohio, United States, 45212
United States, Texas
Clinical Trials Of Texas Inc.
San Antonio, Texas, United States, 78229
United States, Utah
Advanced Clinical Research
West Jordan, Utah, United States, 84088
Argentina
Local Institution
Capital Federal, Buenos Aires, Argentina, 1429
Local Institution
Buenos Aires, Argentina, 1425
Israel
Local Institution
Beer-Sheva, Israel, 84101
Local Institution
Holon, Israel, 58100
Local Institution
Kfar-Saba, Israel, 44281
Local Institution
Zefat, Israel, 13100
Mexico
Local Institution
Monterrey, Nuevo Leon, Mexico, 64460
Local Institution
Durango, Mexico, 34000
Local Institution
Durango, Mexico, 34075 收起 <<
United States, California
... 展开 >>
Research Site
Los Angeles, California, United States
Research Site
San Diego, California, United States
United States, Florida
Research Site
Hollywood, Florida, United States
Research Site
Tallahassee, Florida, United States
Research Site
Tampa, Florida, United States
United States, Michigan
Research Site
Dearborn, Michigan, United States
United States, New York
Research Site
Buffalo, New York, United States
United States, Tennessee
Research Site
Memphis, Tennessee, United States
United States, Virginia
Research Site
Richmond, Virginia, United States
Russian Federation
Research Site
Moscow, Russian Federation
Research Site
Novosibirsk, Russian Federation
Research Site
Saint Petersburg, Russian Federation
South Africa
Research Site
Cape Town, South Africa
Research Site
Pretoria, South Africa
Taiwan
Research Site
Taichung, Taiwan
Research Site
Taipei, Taiwan 收起 <<
China
... 展开 >> Research Site
Baotou, China
Research Site
Beijing, China
Research Site
Benxi, China
Research Site
Changchun, China
Research Site
Chengdu, China
Research Site
Chongqing, China
Research Site
Dalian, China
Research Site
Dongguan, China
Research Site
Foshan, China
Research Site
Fuzhou, China
Research Site
Guangzhou, China
Research Site
Guiyang, China
Research Site
Haikou, China
Research Site
Hangzhou, China
Research Site
Hhht, China
Research Site
Hubei, China
Research Site
Jimo, China
Research Site
Jinan, China
Research Site
Kunming, China
Research Site
Linyi, China
Research Site
Nanjing, China
Research Site
Nantong, China
Research Site
Qingdao, China
Research Site
Shanghai, China
Research Site
Shantou, China
Research Site
Shenyang, China
Research Site
Shiyan, China
Research Site
Suzhou, China
Research Site
Taiyuan, China
Research Site
Tianjin, China
Research Site
Urumqi, China
Research Site
Wenzhou, China
Research Site
Wuhan, China
Research Site
Wuxi, China
Research Site
Xian, China
Research Site
Zhanjiang, China
Research Site
Zhengzhou, China 收起 <<
Germany
... 展开 >> Diabetologische Schwerpunktpraxis Dr. Lorra / Dr. Bonnermann
Bochum, Germany, 44869
Zentrum für klinische Studien Dresden, GWT-TUD GmbH
Dresden, Germany, 01307
Gemeinschaftspraxis Partner der Gesundheit
Essen, Germany, 45355
IKFE Institute for Clinical Research and Development
Mainz, Germany, 55116
Zentrum für Diabetes und Gefäßerkrankungen
Münster, Germany, 48145
Diabetes Zentrum Neuwied
Neuwied, Germany, 56564
ikfe Studiencenter Potsdam GmbH
Potsdam, Germany, 14469 收起 <<
United States, California
... 展开 >>
Research Site
Los Angeles, California, United States
United States, Florida
Research Site
Tallahassee, Florida, United States
United States, Michigan
Research Site
Dearborn, Michigan, United States
United States, Minnesota
Research Site
St. Paul, Minnesota, United States
United States, New York
Research Site
Mineola, New York, United States
United States, Ohio
Research Site
Cleveland, Ohio, United States
United States, Tennessee
Research Site
Memphis, Tennessee, United States
Belgium
Research Site
Namur, Belgium
Canada, Alberta
Research Site
Calgary, Alberta, Canada
India
Research Site
Bangalore, India
Mexico
Research Site
Aguascalientes, Mexico
Research Site
Meridas, Mexico
Research Site
Monterrey, Mexico
Research Site
Veracruz, Mexico
Taiwan
Research Site
Taichung, Taiwan
United Kingdom
Research Site
Leicester, United Kingdom 收起 <<
India
... 展开 >> Research Site
Gujarat, Ahmedabad, India
Research Site
Karnataka, Bangalore, India
Research Site
Tamil Nadu, Chennai, India
Research Site
Tamil Nadu, Coimbatore, India
Research Site
Andhra Pradesh, Hyderabad, India
Research Site
Madhya Pradesh, Indore, India
Research Site
Haryana, Karnal, India
Research Site
Kerala, Kochi, India
Research Site
Maharashtra, Pune, India 收起 <<
China
... 展开 >> Research Site
Beijing, China
Research Site
Changchun, China
Research Site
Fuzhou, China
Research Site
Guangzhou, China
Research Site
Ha'er bing, China
Research Site
Hefei, China
Research Site
Nanchang, China
Research Site
Nanjing, China
Research Site
Shanghai, China
Research Site
ShiJiazhuang, China
Research Site
Shiyan, China 收起 <<
Italy
... 展开 >> Department of Endocrinology and Metabolism, University of Pisa
Recruiting
Pisa, Italy, 56124
Contact: Stefano Del Prato, MD +39 050 995103 stefano.delprato@med.unipi.it
Sub-Investigator: Giuseppe Daniele, MD 收起 <<
Terminated(The study was stopp... 展开 >>ed due to poor enrollment.) 收起 <<
-
United States, Alabama
... 展开 >>
Cardiology, PC
Birmingham, Alabama, United States, 35211
Cardio-Thoracic Surgeons PC
Birmingham, Alabama, United States, 35243
Heart Center Research, LLC
Huntsville, Alabama, United States, 35801
United States, Arkansas
Sparks Regional Medical Center
Fort Smith, Arkansas, United States, 72901
Arkansas Cardiology, PA
Little Rock, Arkansas, United States, 72205
United States, California
Stanford University Medical Center
Palo Alto, California, United States, 94304
United States, Georgia
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
United States, North Carolina
Duke University Medical Center (DUMC)
Durham, North Carolina, United States, 27710
United States, Virginia
Chippenham Medical Center
Richmond, Virginia, United States, 23225
United States, West Virginia
Charleston Area Medical Center (CAMC)
Charleston, West Virginia, United States, 25304 收起 <<
United States, District of Col... 展开 >>umbia
The GW Medical Faculty Associates
Recruiting
Washington, District of Columbia, United States, 20037
Contact: Hassan Awal, MD hawal@mfa.gwu.edu 收起 <<
China
... 展开 >> Research Site
Beijing, China
Research Site
Changchun, China
Research Site
Chuangchun, China
Research Site
Fuzhou, China
Research Site
Guiyang, China
Research Site
Ha'er bin, China
Research Site
Hangzhou, China
Research Site
Hefei, China
Research Site
Jinan, China
Research Site
Nanchang, China
Research Site
Nanjing, China
Research Site
Shanghai, China
Research Site
Shijiazhuang, China
Research Site
Siping, China
Research Site
Tianjin, China
Research Site
Wuxi, China
Research Site
Yueyang, China 收起 <<
China, Hunan
... 展开 >> Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University
Recruiting
Changsha, Hunan, China, 410011
Contact: Zhiguang Zhou, MD/PhD 86-731-85292154 zhouzg@hotmail.com 收起 <<
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