货号:A295732 同义名: 阿洛利停 / SYR-322 free base;SYR 322
Alogliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50 of 6.9 nM that exhibits greater selective than DPP-2, DPP-8 and DPP-9.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | Dipeptidylpeptidase 4 (DPP4) belongs to the S9b gene family of postproline serine peptidases. It acts mostly as a secreted membrane protein, mediating the degradation and inactivation of glucagon-like peptide (GLP)-1 and gastric inhibitory protein (GIP). Alogliptin is a potent, selective inhibitor of the DPP-4 with IC50 value of 2.63 nM in enzymatic assay. And it has nearly 1000-fold higher IC50 for DPP8/9 inhibition than for DPP4 inhibition[3]. In rats, dogs, and monkeys, the absolute oral bioavailability of alogliptin was 45%, 86%, and 72% to 88%, respectively. After a single oral dose of alogliptin, plasma DPP-4 inhibition was observed within 15 min and maximum inhibition was > 90% in rats, dogs, and monkeys; inhibition was sustained for 12 h in rats (43%) and dogs (65%) and 24 h in monkeys (> 80%). In Zucker fa/fa rats, a single dose of alogliptin (0.3, 1, 3, and 10 mg/kg) inhibited plasma DPP-4 (91% to 100% at 2 h and 20% to 66% at 24 h), increased plasma concentration of GLP-1 and early-phase insulin secretion and reduced blood glucose excursion after oral glucose challenge[4]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03492580 | - | Completed | - | United States, New Jersey ... 展开 >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 收起 << | |
NCT02312427 | Heart Failure ... 展开 >> Diabetes Mellitus 收起 << | Phase 4 | Completed | - | Japan ... 展开 >> Mitsui Memorial Hospital Taito-ku, Tokyo, Japan 收起 << |
NCT02528019 | Effects of the DPP-4 Inhibitor... 展开 >>s or SGLT2 Inhibitors on the Protective Actions for Diabetic Complications 收起 << | Phase 4 | Unknown | August 2018 | Japan ... 展开 >> Kurume University Hospital Recruiting Kurume city, Japan, 830-0011 Contact: Nobuhiro Tahara, MD, PhD +81-942-31-7580 ntahara@med.kurume-u.ac.jp Contact: Sho-ichi Yamagishi, MD, PhD +81-942-31-7562 Principal Investigator: Nobuhiro Tahara, MD, PhD 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.95mL 0.59mL 0.29mL |
14.73mL 2.95mL 1.47mL |
29.46mL 5.89mL 2.95mL |
CAS号 | 850649-61-5 |
分子式 | C18H21N5O2 |
分子量 | 339.392 |
别名 | 阿洛利停 ;SYR-322 free base;SYR 322 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,2-8°C |
溶解度 |
DMSO: 105 mg/mL(309.38 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 10 mg/mL(29.46 mM),配合低频超声,并水浴加热至45℃助溶 |
动物实验配方 |