Ambeed.cn

首页 / / / / Alogliptin

阿格列汀 /Alogliptin {[allProObj[0].p_purity_real_show]}

货号:A295732 同义名: 阿洛利停 / SYR-322 free base;SYR 322

Alogliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50 of 6.9 nM that exhibits greater selective than DPP-2, DPP-8 and DPP-9.

Alogliptin 化学结构 CAS号:850649-61-5
Alogliptin 化学结构
CAS号:850649-61-5
Alogliptin 3D分子结构
CAS号:850649-61-5
Alogliptin 化学结构 CAS号:850649-61-5
Alogliptin 3D分子结构 CAS号:850649-61-5
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Alogliptin 纯度/质量文件 产品仅供科研

货号:A295732 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
更多 >

Alogliptin 生物活性

描述 Dipeptidylpeptidase 4 (DPP4) belongs to the S9b gene family of postproline serine peptidases. It acts mostly as a secreted membrane protein, mediating the degradation and inactivation of glucagon-like peptide (GLP)-1 and gastric inhibitory protein (GIP). Alogliptin is a potent, selective inhibitor of the DPP-4 with IC50 value of 2.63 nM in enzymatic assay. And it has nearly 1000-fold higher IC50 for DPP8/9 inhibition than for DPP4 inhibition[3]. In rats, dogs, and monkeys, the absolute oral bioavailability of alogliptin was 45%, 86%, and 72% to 88%, respectively. After a single oral dose of alogliptin, plasma DPP-4 inhibition was observed within 15 min and maximum inhibition was > 90% in rats, dogs, and monkeys; inhibition was sustained for 12 h in rats (43%) and dogs (65%) and 24 h in monkeys (> 80%). In Zucker fa/fa rats, a single dose of alogliptin (0.3, 1, 3, and 10 mg/kg) inhibited plasma DPP-4 (91% to 100% at 2 h and 20% to 66% at 24 h), increased plasma concentration of GLP-1 and early-phase insulin secretion and reduced blood glucose excursion after oral glucose challenge[4].

Alogliptin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03492580 - Completed - United States, New Jersey ... 展开 >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 收起 <<
NCT02312427 Heart Failure ... 展开 >> Diabetes Mellitus 收起 << Phase 4 Completed - Japan ... 展开 >> Mitsui Memorial Hospital Taito-ku, Tokyo, Japan 收起 <<
NCT02528019 Effects of the DPP-4 Inhibitor... 展开 >>s or SGLT2 Inhibitors on the Protective Actions for Diabetic Complications 收起 << Phase 4 Unknown August 2018 Japan ... 展开 >> Kurume University Hospital Recruiting Kurume city, Japan, 830-0011 Contact: Nobuhiro Tahara, MD, PhD    +81-942-31-7580    ntahara@med.kurume-u.ac.jp    Contact: Sho-ichi Yamagishi, MD, PhD    +81-942-31-7562       Principal Investigator: Nobuhiro Tahara, MD, PhD 收起 <<

Alogliptin 参考文献

[1]Moritoh Y, Takeuchi K, et al. The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice. Eur J Pharmacol. 2009 Jan 14;602(2-3):448-54.

[2]Feng J, Zhang Z, et al. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50(10):2297-300.

[3]Huan Y, Jiang Q, Liu JL, Shen ZF. Establishment of a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors. J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:8-12. doi: 10.1016/j.vascn.2014.11.002. Epub 2014 Nov 15. PMID: 25464020.

[4]Lee B, Shi L, Kassel DB, Asakawa T, Takeuchi K, Christopher RJ. Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys. Eur J Pharmacol. 2008 Jul 28;589(1-3):306-14. doi: 10.1016/j.ejphar.2008.04.047. Epub 2008 Apr 26. PMID: 18538760.

Alogliptin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.46mL

5.89mL

2.95mL

Alogliptin 技术信息

CAS号850649-61-5
分子式C18H21N5O2
分子量 339.392
别名 阿洛利停 ;SYR-322 free base;SYR 322
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(309.38 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 10 mg/mL(29.46 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。