MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.
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HazMat fee for 500 gram (Estimated)
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G protein-coupled receptor 119 (GPR119), a class A G protein-coupled receptor (GPCR), is involved in regulating metabolic homoeostasis, with GPR119 agonists targeted for the treatment of type-2 diabetes and obesity. MBX-2982 is a selective, orally-available GPR119 agonist. In cells pretreated with MBX-2982 (1 μM) in “chronic incubation/washout” experiments, cAMP accumulation was significantly increased compared to control cells and the sustained response after “chronic incubation/washout” was high at 84.62 ± 20.22% of acute response. In GLUTag cells, MBX-2982 (1 μM; 120 min) evoked a statistically significant increase in GLP-1 secretion compared to control cells[3]. In C57BL/6 mice, MBX-2982 at a dose of 10 mg/kg increased the plasma GLP-1 levels without a glucose load[4].
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