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抑制剂/激动剂
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葡萄糖苷酶
淀粉葡萄糖苷酶抑制剂 单磷酸肌苷脱氢酶抑制剂 糖尿病
/ Miglitol

Miglitol {[allProObj[0].p_purity_real_show]}

货号：A159516 同义名： 米各尼醇 / BAY1099; BAY-m1099

Miglitol是一种 α-葡萄糖苷酶抑制剂，具有口服活性，可用于治疗糖尿病，抑制葡萄糖的转化。

Miglitol 化学结构 CAS号：72432-03-2
Miglitol 化学结构
CAS号：72432-03-2
Miglitol 3D分子结构
CAS号：72432-03-2
Miglitol 化学结构 CAS号：72432-03-2
Miglitol 3D分子结构 CAS号：72432-03-2
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Miglitol 纯度/质量文件 产品仅供科研

货号：A159516 标准纯度： {[allProObj[0].p_purity_real_show]}
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全球学术期刊中引用的产品

• Adv. Funct. Mater., 2025, 2500696. Ambeed. [ A245395 ]
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• Sci. Adv., 2025, 11(13): eadr0006. Ambeed. [ A152627 ]
• ACS Appl. Mater. Interfaces, 2025, 17(12): 18046-18058. Ambeed. [ A739356 , A171817 ]
• Food Res. Int., 2025, 116191. Ambeed. [ A1452012 ]
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Miglitol 生物活性

描述 Miglitol is an alpha glucosidase inhibitor which delays intestinal absorption of carbohydrates and is used as an adjunctive therapy in the management of type 2 diabetes[3]. Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose. The administration of miglitol significantly decreased the levels of plasma glucose, glycoalbumin and high-sensitivity C-reactive protein, and elevated the high-density lipoprotein-cholesterol level in fatty rats[4]. Miglitol appears to safely ameliorate NASH (steatohepatitis) activity by attenuation of steatosis and lobular/portal inflammation[5]. In the intestine, miglitol treatment significantly suppressed the mRNA expression of apical sodium-dependent bile acid transporter and ATP-binding cassette transporter G5 and G8. In fecal microbiome, the prevalence of prevotella was remarkably reduced and that of clostridium subcluster XIVa was increased by miglitol[6]. Long-term miglitol treatment dose-dependently prevented diet-induced obesity and induced mitochondrial gene expression in brown adipose tissue. Miglitol effectively stimulated energy expenditure in mice fed a high-fat high-monocarbohydrate diet, and intraperitoneal injection of miglitol was sufficient to stimulate energy expenditure in mice[7]. Moreover, miglitol can protect against age-dependent weight gain[8].

Miglitol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01697592 - Completed - -
NCT03492580 - Completed - United States, New Jersey ... 展开 >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 收起 <<
NCT02456428 - Completed - Canada, Quebec ... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 收起 <<

Miglitol 参考文献

[1]Hirose S, Iwahashi Y, et al. Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. Intern Med. 2016;55(9):1137-42.

[2]Joubert PH, Foukaridis GN, Bopape ML. Miglitol may have a blood glucose lowering effect unrelated to inhibition of alpha-glucosidase. Eur J Clin Pharmacol. 1987;31(6):723-4.

[3]LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Miglitol. 2021 Jan 12

[4]Hirata A, Igarashi M, Iwai H, Tominaga M. Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. Horm Metab Res. 2009 Mar;41(3):213-20

[5]Komatsu M, Tanaka N, Kimura T, Fujimori N, Sano K, Horiuchi A, Sugiura A, Yamazaki T, Shibata S, Joshita S, Umemura T, Matsumoto A, Tanaka E. Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients. Hepatol Res. 2018 Dec;48(13):1092-1098

[6]Hamada Y, Goto M, Nishimura G, Nagasaki H, Seino Y, Kamiya H, Nakamura J. The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice. Metabol Open. 2020 Jan 11;5:100024

[7]Sasaki T, Shimpuku M, Kitazumi T, Hiraga H, Nakagawa Y, Shibata H, Okamatsu-Ogura Y, Kikuchi O, Kim HJ, Fujita Y, Maruyama J, Susanti VY, Yokota-Hashimoto H, Kobayashi M, Saito M, Kitamura T. Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. Endocr J. 2013;60(10):1117-29

[8]Sasaki T, Hiraga H, Yokota-Hashimoto H, Kitamura T. Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. Endocr J. 2015;62(5):469-73

Miglitol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.83mL

0.97mL

0.48mL

24.13mL

4.83mL

2.41mL

48.26mL

9.65mL

4.83mL

Miglitol 技术信息

CAS号72432-03-2
分子式C8H17NO5
分子量 207.22
SMILES Code O[C@@H]1[C@@H](CO)N(CCO)C[C@H](O)[C@H]1O
MDL No. MFCD28142869
别名 米各尼醇 ;BAY1099; BAY-m1099; Seibule; Glyset; Diastabol
运输蓝冰
InChI Key IBAQFPQHRJAVAV-ULAWRXDQSA-N
Pubchem ID 441314
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

H2O: 200 mg/mL(965.16 mM)

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一

Tags: Miglitol | 72432-03-2 | BAY1099 | BAY-m1099 | BAY 1099 | BAY-1099 | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Miglitol 纯度/质量文件 | Miglitol 生物活性 | Miglitol 临床数据 | Miglitol 参考文献 | Miglitol 实验方案 | Miglitol 技术信息

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