alpha-Hederin (α-hederin), a monodesmosidic triterpenoid saponin, exhibited promising antitumor potential against a variety of human cancer cell lines. α-hederin significantly inhibited the proliferation of gastric cancer cells and arrested the cell cycle in G1 phase in vitro. α-hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway[3]. α-Hederin could inhibit the proliferation and induce apoptosis of ESCC (esophageal squamous cell carcinoma) via dissipation of the MMP (mitochondrial membrane potential) with simultaneous ROS (reactive oxygen species) generation and activation of the mitochondrial pathway[4]. α‑hederin triggered apoptosis through ROS‑activated mitochondrial signaling pathway and autophagic cell death through ROS dependent AMPK(AMP‑activated protein kinase)/mTOR (mechanistic target of rapamycin) signaling pathway activation in colorectal cancer cells[5]. α-hederin suppressed IL-6-induced EMT (Epithelial-mesenchymal transition) associated with disruption of JAK2/STAT3 signaling in colon cancer cells[6].
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