α-Hederin

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Chemical Structure| 27013-91-8 同义名 : α常春藤皂甙 ;alpha-Hederin;Kalopanaxsaponin A;NSC 106553;Koronaroside A
CAS号 : 27013-91-8
货号 : A640384
分子式 : C41H66O12
纯度 : 99%+
分子量 : 750.956
MDL号 : MFCD00010665
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(139.82 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 alpha-Hederin (α-hederin), a monodesmosidic triterpenoid saponin, exhibited promising antitumor potential against a variety of human cancer cell lines. α-hederin significantly inhibited the proliferation of gastric cancer cells and arrested the cell cycle in G1 phase in vitro. α-hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway[3]. α-Hederin could inhibit the proliferation and induce apoptosis of ESCC (esophageal squamous cell carcinoma) via dissipation of the MMP (mitochondrial membrane potential) with simultaneous ROS (reactive oxygen species) generation and activation of the mitochondrial pathway[4]. α‑hederin triggered apoptosis through ROS‑activated mitochondrial signaling pathway and autophagic cell death through ROS dependent AMPK(AMP‑activated protein kinase)/mTOR (mechanistic target of rapamycin) signaling pathway activation in colorectal cancer cells[5]. α-hederin suppressed IL-6-induced EMT (Epithelial-mesenchymal transition) associated with disruption of JAK2/STAT3 signaling in colon cancer cells[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.33mL

0.27mL

0.13mL

6.66mL

1.33mL

0.67mL

13.32mL

2.66mL

1.33mL
参考文献

[1]Cheng L, Xia TS, et al. The anticancer effect and mechanism of α-hederin on breast cancer cells. Int J Oncol. 2014 Aug;45(2):757-63.

[2]Danloy S, Quetin-Leclercq J, et al. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med. 1994 Feb;60(1):45-9.

[3]Wang J, Deng H, Zhang J, Wu D, Li J, Ma J, Dong W. α-Hederin induces the apoptosis of gastric cancer cells accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway. Phytother Res. 2020 Mar;34(3):601-611

[4]Wang J, Wu D, Zhang J, Liu H, Wu J, Dong W. α-Hederin Induces Apoptosis of Esophageal Squamous Cell Carcinoma via an Oxidative and Mitochondrial-Dependent Pathway. Dig Dis Sci. 2019 Dec;64(12):3528-3538

[5]Sun J, Feng Y, Wang Y, Ji Q, Cai G, Shi L, Wang Y, Huang Y, Zhang J, Li Q. α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation. Int J Oncol. 2019 May;54(5):1601-1612

[6]Sun D, Shen W, Zhang F, Fan H, Xu C, Li L, Tan J, Miao Y, Zhang H, Yang Y, Cheng H. α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells. Biomed Pharmacother. 2018 May;101:107-114