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/ Thymol

麝香草酚 /Thymol {[allProObj[0].p_purity_real_show]}

货号：A142689 同义名： 百里酚 / IPMP;2-isopropyl-5-methylphenol

Thymol 是一种天然单萜酚，具有抗菌、抗氧化和抗炎作用。Thymol 主要用于食品、防腐剂、药物和化妆品的研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Thymol 化学结构 CAS号：89-83-8
Thymol 化学结构
CAS号：89-83-8
Thymol 3D分子结构
CAS号：89-83-8
Thymol 化学结构 CAS号：89-83-8
Thymol 3D分子结构 CAS号：89-83-8
规格 价格 会员价 库存 数量
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Thymol 纯度/质量文件 产品仅供科研

货号：A142689 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 GABA receptor ↓ GABAA receptor ↓ 其他靶点 纯度
Niflumic Acid ✔ 98%
Ginkgolide A ++

GABA receptor, Ki: 14.5 μM

 		98%
Valproic acid sodium ✔ Autophagy,HDAC 97%
Flumazenil ✔ 95%
Bemegride ✔ 98%
Bicuculline +++

GABAA receptor, IC50: 2 μM

 		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Thymol 生物活性

描述 Thymol is a transient receptor potential ankyrin subtype 1 channel, (TRPA1) agonist found in thyme and oregano. Thymol has antioxidant, anti-inflammatory, and antimicrobial properties. Thymol had significant, long-lasting antiproliferative effects in vitro. In vivo, thymol displayed significant antitumor effects in Cal27-derived tumors[3]. Oral administration of Thymol reduces the stress induced IBS (irritable bowel syndrome) significantly altering the stress induced gastrointestinal hypermotility, prolonged the whole gut transit time, and increased abdominal withdrawal reflex suggesting gastrointestinal hypermotility and visceral discomfort caused the onset of depression， and thymol competes with endogenous serotonin and an antagonist, Tropisetron and all have similar binding energies to 5-HT3AR[4]. In PC3 cells, thymol induced [Ca²⁺]i rises by inducing PLC-dependent Ca²⁺release from the endoplasmic reticulum and Ca²⁺entry via PKC-sensitive store-operated Ca²⁺ channels and other unknown channels. Thymol also induced Ca²⁺-dissociated cell death[5].

Thymol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02280148 Driving Not Applicable Completed - China, Beijing ... 展开 >> Beijing Friendship Hospital Beijing, Beijing, China, 100000 收起 <<
NCT03468595 Halitosis Not Applicable Completed - -
NCT02980497 Plaque Gingiv... 展开 >>itis Gum Inflammation Bleeding 收起 << Not Applicable Completed - Brazil ... 展开 >> University of Taubate Taubate, Sao Paulo, Brazil, 12020-270 收起 <<

Thymol 参考文献

[1]Pandey SK, Upadhyay S, Tripathi AK. Insecticidal and repellent activities of thymol from the essential oil of Trachyspermum ammi (Linn) Sprague seeds against Anopheles stephensi. Parasitol Res. 2009 Aug;105(2):507-12.

[2]Botelho MA, Nogueira NA, et al. Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens. Braz J Med Biol Res. 2007 Mar;40(3):349-56.

[3]De La Chapa JJ, Singha PK, Lee DR, Gonzales CB. Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis. J Oral Pathol Med. 2018 Aug;47(7):674-682

[4]Subramaniyam S, Yang S, Diallo BN, Fanshu X, Lei L, Li C, Tastan Bishop Ö, Bhattacharyya S. Oral Phyto-thymol ameliorates the stress induced IBS symptoms. Sci Rep. 2020 Aug 17;10(1):13900

[5]Yeh JH, Chou CT, Chen IS, Lu T, Lin KL, Yu CC, Liang WZ, Chang HT, Kuo CC, Ho CM, Chang WT, Shieh P, Jan CR. Effect of thymol on Ca²⁺ homeostasis and viability in PC3 human prostate cancer cells. Chin J Physiol. 2017 Feb 28;60(1):32-40

Thymol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.66mL

1.33mL

0.67mL

33.28mL

6.66mL

3.33mL

66.57mL

13.31mL

6.66mL

Thymol 技术信息

CAS号89-83-8
分子式C10H14O
分子量 150.218
别名 百里酚 ;IPMP;2-isopropyl-5-methylphenol;NSC 49142;NSC 47821;NSC 11215;p-Cymen-3-ol
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 120 mg/mL(798.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Thymol | IPMP;2-isopropyl-5-methylphenol;NSC 49142;NSC 47821;NSC 11215;p-Cymen-3-ol | 百里酚 | Drug Standard | Other Antibiotics | GABA Receptor | AmBeed-信号通路专用抑制剂 | Thymol 纯度/质量文件 | Thymol 亚型比较 | Thymol 生物活性 | Thymol 临床数据 | Thymol 参考文献 | Thymol 实验方案 | Thymol 技术信息

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