产品说明书
Thymol
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同义名 : | 百里酚 ;IPMP;2-isopropyl-5-methylphenol;NSC 49142;NSC 47821;NSC 11215;p-Cymen-3-ol |
| CAS号 : | 89-83-8 | |
| 货号 : | A142689 | |
| 分子式 : | C10H14O | |
| 纯度 : | 99+% | |
| 分子量 : | 150.218 | |
| MDL号 : | MFCD00002309 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(798.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Thymol is a transient receptor potential ankyrin subtype 1 channel, (TRPA1) agonist found in thyme and oregano. Thymol has antioxidant, anti-inflammatory, and antimicrobial properties. Thymol had significant, long-lasting antiproliferative effects in vitro. In vivo, thymol displayed significant antitumor effects in Cal27-derived tumors[3]. Oral administration of Thymol reduces the stress induced IBS (irritable bowel syndrome) significantly altering the stress induced gastrointestinal hypermotility, prolonged the whole gut transit time, and increased abdominal withdrawal reflex suggesting gastrointestinal hypermotility and visceral discomfort caused the onset of depression， and thymol competes with endogenous serotonin and an antagonist, Tropisetron and all have similar binding energies to 5-HT3AR[4]. In PC3 cells, thymol induced [Ca²⁺]i rises by inducing PLC-dependent Ca²⁺release from the endoplasmic reticulum and Ca²⁺entry via PKC-sensitive store-operated Ca²⁺ channels and other unknown channels. Thymol also induced Ca²⁺-dissociated cell death[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02280148 | Driving | Not Applicable | Completed | - | China, Beijing ... 展开 >> Beijing Friendship Hospital Beijing, Beijing, China, 100000 收起 << |
| NCT03468595 | Halitosis | Not Applicable | Completed | - | - |
| NCT02980497 | Plaque Gingiv... 展开 >>itis Gum Inflammation Bleeding 收起 << | Not Applicable | Completed | - | Brazil ... 展开 >> University of Taubate Taubate, Sao Paulo, Brazil, 12020-270 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.66mL 1.33mL 0.67mL |
33.28mL 6.66mL 3.33mL |
66.57mL 13.31mL 6.66mL |
| 参考文献 |
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