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Tanshinone I

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Chemical Structure| 568-73-0 同义名 : Tanshinone A
CAS号 : 568-73-0
货号 : A108483
分子式 : C18H12O3
纯度 : 97%
分子量 : 276.286
MDL号 : MFCD00210563
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(7.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tanshinone I, a major active principle of Salvia miltiorrhiza with anti-tumor and anti-metastasis effcts. In vitro, Tanshinone-1 had an IC50 value of 7.75 μM in HMEC-1 cells for the 72-h treatment. Tanshinone-1 displayed only marginal proliferation inhibition on HMEC-1 cells even at 50 μM. In endothelial cells, tanshinone-1 almost completely inhibited phosphorylation of Stat3 at Tyr705 [3]. In vivo, Tanshinone I could inhibit apoptosis and inflammation in IL-1β-stimulated CHON-001 cells. Moreover, Tanshinone I treatment markedly decreased the subchondral bone thickness and synovitis scores[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02524964 Left Ventricular Remodeling ... 展开 >> Acute Myocardial Infarction 收起 << Phase 4 Unknown July 2017 China, Guangdong ... 展开 >> Guangdong Provincial Hospital of Chinese Medicine Recruiting Guangzhou, Guangdong, China, 510120 Contact: Minzhou Zhang, Dr.    86-20-81887233 ext 32801    minzhouzhang@yeah.net    Contact: Liheng Guo, Dr.    86-8187236 ext 32907    lihengguo1@yeah.net 收起 <<
NCT01452477 Polycystic Ovary Syndrome Not Applicable Unknown July 2014 China, Heilongjiang ... 展开 >> Heilongjiang University of Chinese Medicine Recruiting Harbin, Heilongjiang, China, 150040 Contact: Wenjuan Shen, doctor    +86-045182118464    shenwenjuankx@163.com    Contact: Yuehui Zhang, doctor    +86-045182118464    manbingPCOS@163.com    Principal Investigator: Wenjuan Shen, doctor          China, Jiangsu Huaian Maternal and Child Health Hospital Recruiting Huaian, Jiangsu, China, 223001 Contact: Huiying Xue, Scholar    +8613505238015    haxuehuiying@126.com    Principal Investigator: Huiying Xue, bachlor          Lianyungang Maternal and Child Health Hospital Active, not recruiting Lianyungang, Jiangsu, China, 222000 China, Jiangxi JiangXi University of Traditional Chinese Medicine Completed Nanchang, Jiangxi, China, 330000 收起 <<
NCT01637675 Pulmonary Hypertension ... 展开 >> Pulmonary Arterial Hypertension Cardiovascular Diseases Lung Diseases Tanshinone IIA Sulfonate 收起 << Phase 2 Phase 3 Unknown December 2014 China, Guangdong ... 展开 >> The First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Jian Wang, MD    +8615013388183    jwang31@jhmi.edu 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.62mL

0.72mL

0.36mL

18.10mL

3.62mL

1.81mL

36.19mL

7.24mL

3.62mL
参考文献

[1]Nizamutdinova IT, Lee GW, et al. Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules. Carcinogenesis. 2008 Oct;29(10):1885-92.

[2]Kim SY, Moon TC, et al. Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.

[3]Wang Y, Li JX, Wang YQ, Miao ZH. Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells. Oncotarget. 2015 Jun 30;6(18):16031-42. doi: 10.18632/oncotarget.3648. PMID: 26202747; PMCID: PMC4599254.

[4]Wang X, Fan J, Ding X, Sun Y, Cui Z, Liu W. Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis. Drug Des Devel Ther. 2019 Oct 15;13:3559-3568. doi: 10.2147/DDDT.S216596. PMID: 31686786; PMCID: PMC6800556.

[5]Kim DH, Kim S, Jeon SJ, et al. Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway. Br J Pharmacol. 2009;158(4):1131-1142.