TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 μM/40 nM, showing selectivity for CK2 over JNK3, ROCK1, and MET (IC50> 10 μM).
Protein kinase CK2 (formerly known as casein kinase 2) is a constitutively-active kinase that is expressed ubiquitously in eukaryotes. CK2 is critical in embryonic development, differentiation, immunity, cell survival, epithelial homeostasis and circadian rhythms and is abnormally elevated in many cancers[2]. TTP 22 is a potent and ATP-competitive CK2 inhibitor, with an IC50 of 100 nM and a Ki of 40 nM. It shows selectivity for CK2 over other kianses such as Jnk3, Rock1, Tie2, Ask1, Met and FGFR1 at 10 μM[3].
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