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Sennoside B

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Chemical Structure| 128-57-4 同义名 : -
CAS号 : 128-57-4
货号 : A535597
分子式 : C42H38O20
纯度 : 99%+
分子量 : 862.739
MDL号 : MFCD00151528
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(121.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PDGFR
描述 Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF(platelet-derived growth factor)-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[3]. The 50% inhibitory concentrations of the four sennosides (A, B, E and F) were 17, 9, 24 and 13 microM, respectively, and the type of inhibition by seenosides A and B with respect to allylamine as the substrate was non-competitive[4]. Intracaecal administration of rhein anthrone, the intraluminally active metabolite of sennosides A and B, to mice quickly induced severe diarrhoea[5]. From acute studies, sennosides could be classified as only slightly toxic in rats and mice after a single oral dose. The LD50 values were about 5,000 mg/kg in both species. In subacute studies with rats (max. 20 mg/kg) and dogs (max. 500 mg/kg), sennosides caused no specific local or systemic toxicity[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.16mL

0.23mL

0.12mL

5.80mL

1.16mL

0.58mL

11.59mL

2.32mL

1.16mL
参考文献

[1]Chen YC, Chang CN, et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22.

[2]Mengs U. Toxic effects of sennosides in laboratory animals and in vitro. Pharmacology. 1988;36 Suppl 1:180-7.

[3]Chen YC, Chang CN, Hsu HC, Chiou SJ, Lee LT, Hseu TH. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22

[4]Hiraoka A, Koike S, Sakaguchi S, Masuda Y, Terai F, Miura I, Kawasaki T, Kawai H, Sakakibara M. The sennoside constituents of rhei rhizoma and sennae folium as inhibitors of serum monoamine oxidase. Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2744-6

[5]Yagi T, Miyawaki Y, Nishikawa T, Yamauchi K, Kuwano S. Involvement of prostaglandin E-like material in the purgative action of rhein anthrone, the intraluminal active metabolite of sennosides A and B in mice. J Pharm Pharmacol. 1988 Jan;40(1):27-30

[6]Mengs U. Toxic effects of sennosides in laboratory animals and in vitro. Pharmacology. 1988;36 Suppl 1:180-7