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野黄芩苷 /Scutellarin {[allProObj[0].p_purity_real_show]}

货号:A126805 同义名: 黄岑素 / Scutellarein 7-O-β-D-glucuronide;Breviscapine

Scutellarin is an active flavonoid that shows anti-tumor activity and anti-proteasome action. It can be isolated from the root of Scutellaria baicalensis Georgi.

Scutellarin 化学结构 CAS号:27740-01-8
Scutellarin 化学结构
CAS号:27740-01-8
Scutellarin 3D分子结构
CAS号:27740-01-8
Scutellarin 化学结构 CAS号:27740-01-8
Scutellarin 3D分子结构 CAS号:27740-01-8
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Scutellarin 纯度/质量文件 产品仅供科研

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产品名称 STAT1 STAT3 STAT5 其他靶点 纯度
Nifuroxazide 98%
Fludarabine 98%
Artesunate 98%
BP-1-102 +++

STAT3, Kd: 504 nM

99%+
Niclosamide ++

STAT3, IC50: 0.7 μM

98%
Napabucasin 98%
Cryptotanshinone ++

STAT3, IC50: 4.6 μM

98%
Stattic +

STAT3, IC50: 5.1 μM

98%
NSC 74859 +

STAT3, IC50: 86 μM

99%+
Ochromycinone 98%
HO-3867 97%
C188-9 ++++

STAT3, Kd: 4.7 nM

99%+
HJC0152 98%
SH5-07 97%
SH-4-54 ++++

STAT3, Kd: 300 nM

+++

STAT5, Kd: 464 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Scutellarin 生物活性

描述 Scutellarin is the major active component extracted from Erigeron breviscapus with antioxidant and anti-inflammation properties. Scutellarin can regulate the expression of GFAP, Notch-1 signaling, and nestin along with that of proinflammatory mediators in reactive astrocytes in ischemic injury[3]. Moreover, Scutellarin-treated breast carcinoma MCF-7 cells had significantly inhibited growth and induced apoptosis[4]. Scutellarin(5 mg/kg/day) can protect against DOX (doxorubicin)-induced acute cardiotoxicity through its antioxidant activity and alterations of heart concentrations[5].

Scutellarin 参考文献

[1]Li Q, Chen Y, et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270.

[2]Qu J, Wang Y, Luo G. Determination of scutellarin in Erigeron breviscapus extract by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2001 Jun 15;919(2):437-41.

[3]Fang M, Yuan Y, Rangarajan P, Lu J, Wu Y, Wang H, Wu C, Ling EA. Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. BMC Neurosci. 2015 Nov 25;16:84. doi: 10.1186/s12868-015-0219-6. PMID: 26608466; PMCID: PMC4660684.

[4]Hou L, Chen L, Fang L. Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. Med Sci Monit. 2017 Oct 28;23:5130-5138. doi: 10.12659/msm.904492. PMID: 29079722; PMCID: PMC5673030.

[5]Sun XP, Wan LL, Yang QJ, Huo Y, Han YL, Guo C. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. Arch Pharm Res. 2017 Jul;40(7):875-883. doi: 10.1007/s12272-017-0907-0. Epub 2017 Mar 17. PMID: 28315259; PMCID: PMC5537312.

Scutellarin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.81mL

2.16mL

1.08mL

21.63mL

4.33mL

2.16mL

Scutellarin 技术信息

CAS号27740-01-8
分子式C21H18O12
分子量 462.36
别名 黄岑素 ;Scutellarein 7-O-β-D-glucuronide;Breviscapine;Scutellarein-7-glucuronide;Breviscapin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 105 mg/mL(227.1 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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