SAR-20347 | TYK2 Inhibitor | AmBeed-信号通路专用抑制剂

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SAR-20347 {[allProObj[0].p_purity_real_show]}

货号：A627263

SAR-20347 is a TYK2 and JAK inhibitor with IC50 values of 0.6, 23, 26 and 41nM for TYK2, JAK1, JAK2 and JAK3, respectively.

SAR-20347 化学结构
CAS号：1450881-55-6

SAR-20347 3D分子结构
CAS号：1450881-55-6

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SAR-20347 纯度/质量文件产品仅供科研

货号：A627263 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

JAK 亚型比较

产品名称	JAK1 ↓ ↑	JAK2 ↓ ↑	JAK3 ↓ ↑	Tyk2 ↓ ↑	其他靶点	纯度
Decernotinib	+++ JAK1, IC50: 11 nM JAK1, Ki: 11 nM	+++ JAK2, Ki: 13 nM	++++ JAK3, Ki: 2.5 nM	+++ TYK2, Ki: 13 nM		{[allProObj[0].p_purity_real_show]}
ZM39923 HCl	+ JAK1, pIC50: 4.4		+ JAK3, pIC50: 7.1		EGFR	{[allProObj[0].p_purity_real_show]}
Cerdulatinib	+++ JAK1, IC50: 12 nM	+++ JAK2, IC50: 6 nM	+++ JAK3, IC50: 8 nM	++++ TYK2, IC50: 0.5 nM		{[allProObj[0].p_purity_real_show]}
Momelotinib	+++ JAK1, IC50: 11 nM	++ JAK2, IC50: 18 nM	+ JAK3, IC50: 155 nM			{[allProObj[0].p_purity_real_show]}
XL019	+ JAK1, IC50: 134.3 nM	++++ JAK2, IC50: 2.2 nM	+ JAK3, IC50: 214.2 nM		FLT3	{[allProObj[0].p_purity_real_show]}
Ruxolitinib	+++ JAK1, IC50: 3.3 nM	++++ JAK2, IC50: 2.8 nM				{[allProObj[0].p_purity_real_show]}
Tofacitinib	+ JAK1, IC50: 112 nM	++ JAK2, IC50: 20 nM	++++ JAK3, IC50: 1 nM			{[allProObj[0].p_purity_real_show]}
Ruxolitinib (S enantiomer)	+++ JAK1, IC50: 3.3 nM	++++ JAK2, IC50: 2.8 nM		++ TYK2, IC50: 19 nM		{[allProObj[0].p_purity_real_show]}
Filgotinib	+++ JAK1, IC50: 10 nM	++ JAK2, IC50: 28 nM	+ JAK3, IC50: 810 nM	+ TYK2, IC50: 116 nM		{[allProObj[0].p_purity_real_show]}
Baricitinib	+++ JAK1, IC50: 5.9 nM	+++ JAK2, IC50: 5.7 nM		++ TYK2, IC50: 53 nM		{[allProObj[0].p_purity_real_show]}
Gandotinib	++ JAK1, IC50: 19.8 nM	++++ JAK2, IC50: 0.288 nM JAK2 (V617F), Ki: 0.245 nM	++ JAK3, IC50: 48.0 nM	++ TYK2, IC50: 44 nM	FLT3	{[allProObj[0].p_purity_real_show]}
Oclacitinib maleate	+++ JAK1, IC50: 10nM	++ JAK2, IC50: 18nM	+ JAK3, IC50: 99nM	+ TYK2, IC50: 84nM		{[allProObj[0].p_purity_real_show]}
NVP-BSK805 2HCl	++ JAK1, IC50: 31.63 nM	++++ JAK2, IC50: ~0.5 nM	++ JAK3, IC50: 18.68 nM	+++ TYK2, IC50: 10.76 nM		{[allProObj[0].p_purity_real_show]}
Peficitinib		✔				{[allProObj[0].p_purity_real_show]}
Go6976		✔			FLT3	{[allProObj[0].p_purity_real_show]}
AZD-1480		++++ JAK2, IC50: 0.26 nM				{[allProObj[0].p_purity_real_show]}
Fedratinib		+++ JAK2, IC50: 3 nM JAK2 (V617F), IC50: 3 nM			RET,FLT3	{[allProObj[0].p_purity_real_show]}
WP1066		+ JAK2, IC50: 2.3 μM				{[allProObj[0].p_purity_real_show]}
Curcumol		✔				{[allProObj[0].p_purity_real_show]}
AZ960		++++ JAK2, IC50: <3 nM JAK2, Ki: 0.45 nM				{[allProObj[0].p_purity_real_show]}
GLPG0634 analog		✔				{[allProObj[0].p_purity_real_show]}
CEP-33779		++++ JAK2, IC50: 1.8 nM				{[allProObj[0].p_purity_real_show]}
FLLL32		+ JAK2, IC50: <5 μM				{[allProObj[0].p_purity_real_show]}
WHI-P154			+ JAK3, IC50: 1.8 μM		Src,VEGFR,EGFR	{[allProObj[0].p_purity_real_show]}
BMS-911543		++++ JAK2, IC50: 1.1 nM	+ JAK3, IC50: 75 nM	++ TYK2, IC50: 66 nM		{[allProObj[0].p_purity_real_show]}
TG101209		+++ JAK2, IC50: 6 nM	+ JAK3, IC50: 169 nM		RET,FLT3	{[allProObj[0].p_purity_real_show]}
AT9283		++++ JAK2, IC50: 1.2 nM	++++ JAK3, IC50: 1.1 nM			{[allProObj[0].p_purity_real_show]}
Pacritinib		++ JAK2, IC50: 23 nM JAK2 (V617F), IC50: 19 nM	+ JAK3, IC50: 520 nM	++ TYK2, IC50: 50 nM	FLT3	{[allProObj[0].p_purity_real_show]}
Tofacitinib citrate		++ JAK2, IC50: 20 nM	++++ JAK3, IC50: 1 nM			{[allProObj[0].p_purity_real_show]}
FM-381			++++ JAK3, IC50: 127 pM			{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

SAR-20347 生物活性

描述

SAR-20347 acts as an inhibitor for TYK2, JAK1, JAK2, and JAK3, with respective IC50 values of 0.6, 23, 26, and 41 nM. It effectively blocks IL-12-induced STAT4 phosphorylation in NK-92 cells, a process dependent on TYK2, with an IC50 of 126 nM. The inhibitor shows a hierarchy of selectivity: TYK2 > JAK1 > JAK2 > JAK3. In the absence of IL-12, no IFN-γ is detectable in cells, whereas the presence of IL-12 and SAR-20347 results in a dose-responsive decrease in IFN-γ production. Additionally, SAR-20347 curtails the production of SEAP in a dose-dependent manner, with the most significant reduction observed at a concentration of 5 μM^[1].

SAR-20347 动物研究

Animal study

At dosage of 60 mg/kg, SAR-20347 reduces IFN-γ serum production by 91% compared to animals treated with a vehicle, indicating effective in vivo inhibition of TYK2 signaling. Additionally, SAR-20347 significantly lowers IL-17 production, as evidenced by average signal intensity measurements, aligning with gene expression data^[1].

SAR-20347 参考文献

[1]Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014 Oct 1;193(7):3278-87.

SAR-20347 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.24mL

2.25mL

1.12mL

22.48mL

4.50mL

2.25mL

SAR-20347 技术信息

CAS号	1450881-55-6
分子式	C₂₁H₁₈ClFN₄O₄
分子量	444.843

别名
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(236.04 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

SAR-20347 {[allProObj[0].p_purity_real_show]}

SAR-20347 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

SAR-20347 质控信息

SAR-20347 生物活性

SAR-20347 动物研究

SAR-20347 参考文献

SAR-20347 实验方案

SAR-20347 技术信息

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SAR-20347 {[allProObj[0].p_purity_real_show]}

SAR-20347 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

SAR-20347 质控信息

SAR-20347 生物活性

SAR-20347 动物研究

SAR-20347 参考文献

SAR-20347 实验方案

SAR-20347 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

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