产品说明书

SAR-20347

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Chemical Structure| 1450881-55-6 同义名 : -
CAS号 : 1450881-55-6
货号 : A627263
分子式 : C21H18ClFN4O4
纯度 : 99%+
分子量 : 444.843
MDL号 : MFCD28502117
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(236.04 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SAR-20347 acts as an inhibitor for TYK2, JAK1, JAK2, and JAK3, with respective IC50 values of 0.6, 23, 26, and 41 nM. It effectively blocks IL-12-induced STAT4 phosphorylation in NK-92 cells, a process dependent on TYK2, with an IC50 of 126 nM. The inhibitor shows a hierarchy of selectivity: TYK2 > JAK1 > JAK2 > JAK3. In the absence of IL-12, no IFN-γ is detectable in cells, whereas the presence of IL-12 and SAR-20347 results in a dose-responsive decrease in IFN-γ production. Additionally, SAR-20347 curtails the production of SEAP in a dose-dependent manner, with the most significant reduction observed at a concentration of 5 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.24mL

2.25mL

1.12mL

22.48mL

4.50mL

2.25mL
参考文献

[1]Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014 Oct 1;193(7):3278-87.