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鲁斯可皂苷元 /Ruscogenin {[allProObj[0].p_purity_real_show]}

货号:A934971

Ruscogenin, a natural product isolated and purified from the root of Ophiopogon japonicus with significant anti-inflammatory and anti-thrombotic activities, significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, protects the brain against ischemic damage caused by middle cerebral artery occlusion (MCAO) which may be through downregulation of NF-κB-mediated inflammatory responses, inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways, and may attenuate high-fat diet (HFD)-induced steatohepatitis through downregulation of NF- κB-mediated inflammatory responses, reducing hepatic lipogenic gene expression, and upregulating proteins in β-oxidation pathway.

Ruscogenin 化学结构 CAS号:472-11-7
Ruscogenin 化学结构
CAS号:472-11-7
Ruscogenin 3D分子结构
CAS号:472-11-7
Ruscogenin 化学结构 CAS号:472-11-7
Ruscogenin 3D分子结构 CAS号:472-11-7
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Ruscogenin 纯度/质量文件 产品仅供科研

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Ruscogenin 生物活性

描述 Ruscogenin, a natural product isolated and purified from the root of Ophiopogon japonicus with significant anti-inflammatory and anti-thrombotic activities, significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, protects the brain against ischemic damage caused by middle cerebral artery occlusion (MCAO) which may be through downregulation of NF-κB-mediated inflammatory responses, inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways, and may attenuate high-fat diet (HFD)-induced steatohepatitis through downregulation of NF- κB-mediated inflammatory responses, reducing hepatic lipogenic gene expression, and upregulating proteins in β-oxidation pathway.

Ruscogenin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01984931 Nausea Vomiti... 展开 >>ng 收起 << Phase 3 Unknown December 2013 Korea, Republic of ... 展开 >> Chungmu General Hopsital Recruiting Seoul, Yeongdeungpo-gu, Korea, Republic of, 150-034 Contact: Sang Hoon Lhee, MD, Phd    +82 (2) 2068/4525    cmirb@naver.com    Principal Investigator: Paolo Alan B Tabar, MD 收起 <<

Ruscogenin 参考文献

[1]Ji PY, Li ZW, et al. Rapid determination of ruscogenin in rat plasma with application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 15;985:71-4.

[2]Lu HJ, Liou SS, et al. Ruscogenin protects against high-fat diet-induced nonalcoholic steatohepatitis in hamsters. Planta Med. 2014 Jul;80(11):870-9.

Ruscogenin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.61mL

2.32mL

1.16mL

23.22mL

4.64mL

2.32mL

Ruscogenin 技术信息

CAS号472-11-7
分子式C27H42O4
分子量 430.62
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

溶解方案

DMSO: 25 mg/mL(58.06 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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