产品说明书
Ruscogenin
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同义名 : | - |
| CAS号 : | 472-11-7 | |
| 货号 : | A934971 | |
| 分子式 : | C27H42O4 | |
| 纯度 : | 98% | |
| 分子量 : | 430.62 | |
| MDL号 : | MFCD00210550 | |
| 存储条件： |
粉末 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(58.06 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ruscogenin, a natural product isolated and purified from the root of Ophiopogon japonicus with significant anti-inflammatory and anti-thrombotic activities, significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, protects the brain against ischemic damage caused by middle cerebral artery occlusion (MCAO) which may be through downregulation of NF-κB-mediated inflammatory responses, inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways, and may attenuate high-fat diet (HFD)-induced steatohepatitis through downregulation of NF- κB-mediated inflammatory responses, reducing hepatic lipogenic gene expression, and upregulating proteins in β-oxidation pathway. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01984931 | Nausea Vomiti... 展开 >>ng 收起 << | Phase 3 | Unknown | December 2013 | Korea, Republic of ... 展开 >> Chungmu General Hopsital Recruiting Seoul, Yeongdeungpo-gu, Korea, Republic of, 150-034 Contact: Sang Hoon Lhee, MD, Phd +82 (2) 2068/4525 cmirb@naver.com Principal Investigator: Paolo Alan B Tabar, MD 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.32mL 0.46mL 0.23mL |
11.61mL 2.32mL 1.16mL |
23.22mL 4.64mL 2.32mL |
| 参考文献 |
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