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原人参二醇 /Protopanaxdiol {[allProObj[0].p_purity_real_show]}

货号：A916196 同义名： 20 (S)-原人参二醇 / (20S)-Protopanaxadiol;20-Epiprotopanaxadiol

(20S)-Protopanaxadiol is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin and an apoptosis inducer.

Protopanaxdiol 化学结构 CAS号：30636-90-9
Protopanaxdiol 化学结构
CAS号：30636-90-9
Protopanaxdiol 3D分子结构
CAS号：30636-90-9
Protopanaxdiol 化学结构 CAS号：30636-90-9
Protopanaxdiol 3D分子结构 CAS号：30636-90-9
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Protopanaxdiol 纯度/质量文件 产品仅供科研

货号：A916196 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
更多 >

Protopanaxdiol 生物活性

描述 (20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin-apoptosis inducer. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant[3]. 20S-protopanaxadiol (PPD) showed the most potent cytotoxic activity in both LX-2 cells and primary activated HSCs (hepatic stellate cells) . In addition, 20S-PPD concentration-dependently increased the phosphorylation of AMPK, and compound C prevented 20S-PPD-induced cytotoxicity and mitochondrial dysfunction. Moreover, 20S-PPD increased the phosphorylation of liver kinase B1 (LKB1), an upstream kinase of AMPK. Likewise, transfection of LX-2 cells with LKB1 siRNA reduced the cytotoxic effect of 20S-PPD[4]. PPD (>30 μM) suppressed cell proliferation by arresting cell cycle in G0/1 phase and triggering cells apoptosis as shown by cell viability assay, flow cytometry analysis and colony formation assay, whereas lower dose of PPD (<20 μM) decreased metastatic potential of MDA-MB-231 and SUM159 cells through direct inhibition of cell adhesion, motility and invasiveness[5].

Protopanaxdiol 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
COLO205 cells Cytotoxicity assay 72 h Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay 21216145
Hep3B cells Cytotoxicity assay 72 h Cytotoxicity against human Hep3B cells after 72 hrs by MTT assay 22342101
HepG2 cells Cytotoxicity assay 72 h Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay 21216145
HepG2 cells Cytotoxicity assay 48 h Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay 26420067

Protopanaxdiol 参考文献

[1]Wanderi C, Kim E, et al. Ginsenoside 20(S)-Protopanaxadiol Suppresses Viability of Human Glioblastoma Cells via Down-regulation of Cell Adhesion Proteins and Cell-cycle Arrest. Anticancer Res. 2016 Mar;36(3):925-32.

[2]Oh HA, Kim DE, Choi HJ, Kim NJ, Kim DH. Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice. Biol Pharm Bull. 2015;38(2):331-5.

[3]Liu GY, Bu X, Yan H, Jia WW. 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod. 2007 Feb;70(2):259-64

[4]Park SM, Jung EH, Kim JK, Jegal KH, Park CA, Cho IJ, Kim SC. 20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1-AMP-activated protein kinase activation. J Ginseng Res. 2017 Jul;41(3):392-402

[5]Peng B, He R, Xu Q, Yang Y, Hu Q, Hou H, Liu X, Li J. Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway. Pharmacol Res. 2019 Apr;142:1-13

Protopanaxdiol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.85mL

2.17mL

1.09mL

21.70mL

4.34mL

2.17mL

Protopanaxdiol 技术信息

CAS号30636-90-9
分子式C30H52O3
分子量 460.732
别名 20 (S)-原人参二醇 ;(20S)-Protopanaxadiol;20-Epiprotopanaxadiol;20S-Protopanaxadiol;20(S)-Protopanaxadiol;20(S)-APPD
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 50 mg/mL(108.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: (20S)-Protopanaxadiol | 30636-90-9 | 20-Epiprotopanaxadiol | 20(S)-APPD | Akt activity inhibitor | Membrane Transporter/Ion Channel | NF-κB | Metabolic Enzyme/Protease | Immunology/Inflammation | Apoptosis | P-glycoprotein | Reactive Oxygen Species | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Protopanaxdiol 纯度/质量文件 | Protopanaxdiol 生物活性 | Protopanaxdiol 细胞研究 | Protopanaxdiol 参考文献 | Protopanaxdiol 实验方案 | Protopanaxdiol 技术信息

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