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/ Procyanidin A2

原花青素 A2 /Procyanidin A2 {[allProObj[0].p_purity_real_show]}

货号：A370837 同义名： (+)-Epicatechin-(4β-8,2β-O-7)-epicatechin;Procyanidol A2

Procyanidin A2, a natural product isolated and purified from the rhizomes of Belamcanda chinensis (L.) DC., blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression, and has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO.

Procyanidin A2 化学结构 CAS号：41743-41-3
Procyanidin A2 化学结构
CAS号：41743-41-3
Procyanidin A2 3D分子结构
CAS号：41743-41-3
Procyanidin A2 化学结构 CAS号：41743-41-3
Procyanidin A2 3D分子结构 CAS号：41743-41-3
规格 价格 会员价 库存 数量
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Procyanidin A2 纯度/质量文件 产品仅供科研

货号：A370837 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 20S proteasome ↓ Proteasome ↓ 其他靶点 纯度
Ixazomib ++++

20S proteasome, IC50: 3.4 nM

20S proteasome, Ki: 0.93 nM

 		99%+
Delanzomib +++

Chymotrypsin-like proteasome, IC50: 3.8 nM

 		98%
Celastrol +

20S proteasome, IC50: 2.5 μM

 		98%
MLN9708 +++

20S proteasome, IC50: 3.4 nM

20S proteasome, Ki: 0.93 nM

 		99%
Bortezomib ++++

20S proteasome, Ki: 0.6 nM

 		98%
Oprozomib ++

20S proteasome LMP7, IC50: 82 nM

20S proteasome β5, IC50: 36 nM

 		99%+
Epoxomicin ✔ 99%
PI-1840 ++

Chymotrypsin-like proteasome, IC50: 27 nM

 		98%
VR23 +++

Chymotrypsin-like proteasomes, IC50: 3 μM

Trypsin-like proteasomes, IC50: 1 nM

 		98%
Carfilzomib ++

Proteasome, IC50: 5 nM

 		98%
(R)-MG-132 +

Proteasome, IC50: 100 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Procyanidin A2 生物活性

描述 Procyanidin A2, a natural product isolated and purified from the rhizomes of Belamcanda chinensis (L.) DC., blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression, and has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO.

Procyanidin A2 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03553225 Healthy Men and Women Not Applicable Recruiting December 30, 2018 United Kingdom ... 展开 >> King's College London Recruiting London, United Kingdom, SE1 9NH Contact: Mariam Bapir, M.Sc.    02074844162 ext 4162    mariam.bapir@kcl.ac.uk 收起 <<
NCT01687114 Urinary Tract Infection Not Applicable Completed - United States, Massachusetts ... 展开 >> Jean Mayer USDA Human Nutrition Research Center on Aging Boston, Massachusetts, United States, 02111 收起 <<
NCT01099150 Cardiovascular Disease Not Applicable Completed - United Kingdom ... 展开 >> University of Aberdeen Rowett Institute of Nutrition and Health Aberdeen, Aberdeenshire, United Kingdom, AB21 9SB 收起 <<

Procyanidin A2 参考文献

[1]De Taeye C, Caullet G, et al. Procyanidin A2 and Its Degradation Products in Raw, Fermented, and Roasted Cocoa. J Agric Food Chem. 2017 Mar 1;65(8):1715-1723.

[2]Coleman SL, Kruger MC, et al. Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells. Int J Mol Sci. 2016 Nov 12;17(11).

Procyanidin A2 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.67mL

1.73mL

0.87mL

17.35mL

3.47mL

1.73mL

Procyanidin A2 技术信息

CAS号41743-41-3
分子式C30H24O12
分子量 576.504
别名 (+)-Epicatechin-(4β-8,2β-O-7)-epicatechin;Procyanidol A2;Procyanidin dimer A2;Proanthocyanidin A2
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 105 mg/mL(182.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Procyanidin A2 | 41743-41-3 | Procyanidin A 2 | Procyanidin A-2 | Bacterial Inhibitor | Anti-infection | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Procyanidin A2 纯度/质量文件 | Procyanidin A2 亚型比较 | Procyanidin A2 生物活性 | Procyanidin A2 临床数据 | Procyanidin A2 参考文献 | Procyanidin A2 实验方案 | Procyanidin A2 技术信息

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