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Procyanidin A2
原花青素 A2 /Procyanidin A2
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货号：A370837
同义名：
(+)-Epicatechin-(4β-8,2β-O-7)-epicatechin;Procyanidol A2
Procyanidin A2 是一种从箭毒草（Belamcanda chinensis）根茎中分离纯化的天然产物，能够通过促进 rpn-3 表达增强蛋白酶体活性，抑制 LPS 激活的 RAW 264.7 巨噬细胞中的可诱导一氧化氮合酶（iNOS）及 NO 生成，具有抗炎作用。
Procyanidin A2 化学结构
Procyanidin A2 3D分子结构
规格
价格
会员价
库存
数量
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Procyanidin A2 纯度/质量文件 产品仅供科研
货号：A370837
标准纯度：
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产品说明书
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Procyanidin A2 质控信息
Ixazomib
++++
20S proteasome, Ki: 0.93 nM
20S proteasome, IC50: 3.4 nM
99%+
Delanzomib
+++
Chymotrypsin-like proteasome, IC50: 3.8 nM
98%
Celastrol
+
20S proteasome, IC50: 2.5 μM
98%
MLN9708
+++
20S proteasome, Ki: 0.93 nM
20S proteasome, IC50: 3.4 nM
99%
Bortezomib
++++
20S proteasome, Ki: 0.6 nM
98%
Oprozomib
++
20S proteasome β5, IC50: 36 nM
20S proteasome LMP7, IC50: 82 nM
99%+
Epoxomicin
✔
99%
PI-1840
++
Chymotrypsin-like proteasome, IC50: 27 nM
98%
VR23
+++
Chymotrypsin-like proteasomes, IC50: 3 μM
Trypsin-like proteasomes, IC50: 1 nM
99%
Carfilzomib
++
98%
(R)-MG-132
+
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Procyanidin A2 生物活性
描述
Procyanidin A2, a natural product isolated and purified from the rhizomes of Belamcanda chinensis (L.) DC., blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression, and has anti-inflammatory mechanism in LPS-activated RAW 264.7 macrophages, by reducing the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO.
Procyanidin A2 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT03553225
Healthy Men and Women
Not Applicable
Recruiting
December 30, 2018
United Kingdom
... 展开 >> King's College London
Recruiting
London, United Kingdom, SE1 9NH
Contact: Mariam Bapir, M.Sc. 02074844162 ext 4162 mariam.bapir@kcl.ac.uk 收起 <<
NCT01687114
Urinary Tract Infection
Not Applicable
Completed
-
United States, Massachusetts
... 展开 >>
Jean Mayer USDA Human Nutrition Research Center on Aging
Boston, Massachusetts, United States, 02111 收起 <<
NCT01099150
Cardiovascular Disease
Not Applicable
Completed
-
United Kingdom
... 展开 >> University of Aberdeen Rowett Institute of Nutrition and Health
Aberdeen, Aberdeenshire, United Kingdom, AB21 9SB 收起 <<
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Procyanidin A2 参考文献
Procyanidin A2 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.73mL
0.35mL
0.17mL
8.67mL
1.73mL
0.87mL
17.35mL
3.47mL
1.73mL
Procyanidin A2 技术信息
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