There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Pranlukast is a selective, competitive antagonist of the cysteinyl leukotrienes, leukotriene (LT) C4, LTD4 and LTE4, antagonising binding at the cysteinyl leukotriene type 1 (CysLT1) receptor. In isolated human bronchial smooth muscle preparations, pranlukast caused a concentrationdependent inhibition or reversal of LTC4-, LTD4- and house dust antigen-induced bronchial contraction, but had minimal or no effect on histamine (H)- prostaglandin F2α-, acetylcholine- or thromboxane, A2 (TXA2) mimetic agonist-induced contraction (at 37°C)[3]. In vitro , antigen-induced contraction was inhibited more effectively with pranlukast than with an H1-receptor antagonist; however, pranlukast in combination with an H1-receptor antagonist was more potent than either agent alone[4].Pranlukast has shown a range of anti-inflammatory effects on airways in animal models, including attenuation or inhibition of microvascular leakage in the trachea, bronchi and small airways,LTD4-, capsaicin- or allergen-induced eosinophilia in bronchoalveolar lavage fluid (BAL), bronchial epithelial and subepithelial tissue or lung parenchyma and the expression of mRNA for interleukin-5 in BAL cells[5]. In addition, pranlukast inhibited airway smooth muscle DNA synthesis and reduced allergen-induced airway smooth muscle cell thickness in repeatedly ovalbumin-sensitised rats[6].Animal models show that pranlukast is cleared through metabolic transformation (primarily glucuronic acid conjugation); an in vitro study indicated that the drug is metabolised via cytochrome P450 (CYP) enzymes. The main metabolites formed are mono- and dihydroxylated molecules and their glucuronide conjugates[7].
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Japan
... 展开 >> Chubu region
Chubu, Japan
Hokuriku region
Hokuriku, Japan
Kanto region
Kanto, Japan
Kinki region
Kinki, Japan
Kyushu region
Kyushu, Japan
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Tohoku, Japan 收起 <<
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