PF-4708671
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货号：A130606
同义名：
PF-04708671
PF-4708671是一种强效、细胞可渗透的 S6K1 抑制剂，Ki 为 20 nM，IC50 为 160 nM。
PF-4708671 化学结构
PF-4708671 3D分子结构
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PF-4708671 纯度/质量文件 产品仅供科研
货号：A130606
标准纯度：
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产品说明书
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PF-4708671 质控信息
PF-4708671 生物活性
描述
PF-4708671 is the first reported highly specific p70 S6K1 (p70 ribosomal S6 kinase) inhibitor with Ki value of 20nM and IC50 value of 160nM. PF-4708671 at concentration of 3μM and 10μM prevented the S6K1-mediated phosphorylation of S6 protein (S235/236, S240/S244) in response to IGF-1, while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Also, it dose-dependently induced phosphorylation of S6K1 at Thr229 and Thr389 at concentration ranging in 3-10μM in HEK-293 cells after serum starvation for 16h, dependent upon mTORC1[2]
PF-4708671 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
22RV1
Growth Inhibition Assay
IC50=47.9015 μM
SANGER
23132-87
Growth Inhibition Assay
IC50=44.2978 μM
SANGER
639-V
Growth Inhibition Assay
IC50=84.6129 μM
SANGER
647-V
Growth Inhibition Assay
IC50=12.3582 μM
SANGER
展开
PF-4708671 动物研究
Dose
Mice: 10 mg/kg - 100 mg/kg[2]
Administration
i.p.
PF-4708671 参考文献
[1] Pearce LR, Alton GR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.
[2] Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55. doi: 10.1042/BJ20101024. PMID: 20704563.
PF-4708671 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.56mL
0.51mL
0.26mL
12.81mL
2.56mL
1.28mL
25.61mL
5.12mL
2.56mL
PF-4708671 技术信息
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