There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
PD 198306 is a selective MAPK/ERK kinase inhibitor, which significantly reduces the Streptozocin-induced increase in active ERK1 and 2 levels[1].At a concentration of 10 μM for 36 hours, PD 198306 significantly inhibited Tha-GFP replication by 25%[2].In iPSC cells, at a concentration of 5 μM, PD 198306 significantly reduced Tha-Crimson replication by 20% within 18 hours, but this result could not be confirmed at 36 hours[2].
PD 198306 动物研究
Animal study
Administered using intrathecal injection (1-30 μg per 10 μL), PD 198306 dose-dependently (1-30 μg) blocked static allodynia both in streptozotocin and in chronic constriction injury (CCI) rat models of neuropathic pain[1].
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