产品说明书

	同义名 :	-
	CAS号 :	212631-61-3
	货号 :	A1209818
	分子式 :	C18H16F3IN2O2
	纯度 :	97%
	分子量 :	476.231
	MDL号 :	MFCD08690428
	存储条件：	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

PD 198306 is a selective MAPK/ERK kinase inhibitor, which significantly reduces the Streptozocin-induced increase in active ERK1 and 2 levels[1].At a concentration of 10 μM for 36 hours, PD 198306 significantly inhibited Tha-GFP replication by 25%[2].In iPSC cells, at a concentration of 5 μM, PD 198306 significantly reduced Tha-Crimson replication by 20% within 18 hours, but this result could not be confirmed at 36 hours[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.10mL 0.42mL 0.21mL	10.50mL 2.10mL 1.05mL	21.00mL 4.20mL 2.10mL

参考文献
[1]A Ciruela, et al. Identification of MEK1 as a novel target for the treatment of neuropathic pain. Br J Pharmacol. 2003 Mar;138(5):751-6. [2]Benoit Besson, et al. Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection. mSphere. 2019 May 22;4(3):e00047-19.