GSK1059865是一种食欲素1受体 (orexin 1 receptor) 的有效拮抗剂，广泛用于研究与食欲和觉醒调节相关的神经系统疾病。

Firazorexton是一种具有口服活性、能够透过血脑屏障的 OX2R 激动剂，具有改善嗜睡病等睡眠障碍的潜力。该化合物能够有效激活食欲素受体，在神经系统疾病的治疗中具有广泛的应用前景。

SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, and exhibits 50-fold selectivity over OX2 receptor.

SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with pKb of 7.2.

Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.

TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).

YNT 185 is potent and selective orexin OX2 receptor agonist with EC50 of 28 nM at human OX2 expressed in CHO cells. YNT 185 displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells).

MK-1064 is a selective orexin 2 receptor antagonist(2-SORA) for the research of insomnia.

Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.

PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.

Oxytocin acetate is a mammalian neurohypophysial hormone and its actions are mediated by specific, high-affinity oxytocin receptors and ligand of oxytocin receptor.

EMPA is highly potent, selective OX2 receptor antagonist with IC50 values of 2.3 nM and 1900 nM for OX2 and OX1 respectively.

SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).

Almorexant 是一种强效且竞争性的双重食欲素 1 受体 (OX1) / 食欲素 2 受体 (OX2) 拮抗剂，对 OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。

Orexin 2 receptor agonist is a potent and selective OX2R agonist with EC50 of 23 nM.

MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.