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氧化白藜芦醇 /Oxyresveratrol {[allProObj[0].p_purity_real_show]}

货号:A158758 同义名: 氧化白黎芦醇 / trans-Oxyresveratrol;trans-2',3,4',5-Tetramethoxystilbene

Oxyresveratrol is a naturallly occuring stilbenoid found in the heartwood of Artocarpus lakoocha, which works as a potent tyrosinase inhibitor and also possesses anti-proliferative, anti-inflammatory, and cardioprotective properties.

Oxyresveratrol 化学结构 CAS号:29700-22-9
Oxyresveratrol 化学结构
CAS号:29700-22-9
Oxyresveratrol 3D分子结构
CAS号:29700-22-9
Oxyresveratrol 化学结构 CAS号:29700-22-9
Oxyresveratrol 3D分子结构 CAS号:29700-22-9
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Oxyresveratrol 纯度/质量文件 产品仅供科研

货号:A158758 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 diphenolase monophenolase tyrosinase 其他靶点 纯度
Hexylresorcinol +++

diphenolase, IC50: 0.85 μM

++

monophenolase, IC50: 1.24 μM

+++

monophenolase, IC50: 0.85 μM

diphenolase, IC50: 0.85 μM

99%+
Aloin 98%
Arbutin +

tyrosinase, IC50: 1.09 mM

98%
Monobenzone 98%
Deoxyarbutin ++++

tyrosinase, IC50: 50 nM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Oxyresveratrol 生物活性

描述 Oxyresveratrol(OXY), a stilbene extracted from C. mori root, its bioactivities include antioxidation, anti-inflammatory, neuroprotective, anti-viral, and tyrosinase-inhibitory activities[3]. Oxyresveratrol treatment of MDA-MB-231 cells showed the IC50 value at 48 h calculated from the MTT assay was 42 μM [4].OXY (10 μM) possesses an estrogenic activity and can induce proliferation of MCF-7 cells and upregulation of ERα/β expression [3].Oxyresveratrol ( 100 μM )dose-dependently inhibited lipid accumulation.The adipocyte markers of Pparγ and Fabp4 expressions were consistently suppressed by oxyresveratrol in the 3T3-L1 cells[5].

Oxyresveratrol 参考文献

[1]Chatsumpun N, Chuanasa T, et al. Oxyresveratrol: Structural Modification and Evaluation of Biological Activities. Molecules. 2016 Apr 19;21(4):489.

[2]Lorenz P, Roychowdhury S, et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide. 2003 Sep;9(2):64-76.

[3]Wei J, Chen JR, Pais EMA, Wang TY, Miao L, Li L, Li LY, Qiu F, Hu LM, Gao XM, Fan GW. Oxyresveratrol Is a Phytoestrogen Exerting Anti-inflammatory Effects Through NF-κB and Estrogen Receptor Signaling. Inflammation. 2017 Aug;40(4):1285-1296. doi: 10.1007/s10753-017-0572-y. PMID: 28484893.

[4]Sunilkumar D, Drishya G, Chandrasekharan A, Shaji SK, Bose C, Jossart J, Perry JJP, Mishra N, Kumar GB, Nair BG. Oxyresveratrol drives caspase-independent apoptosis-like cell death in MDA-MB-231 breast cancer cells through the induction of ROS. Biochem Pharmacol. 2020 Mar;173:113724. doi: 10.1016/j.bcp.2019.113724. Epub 2019 Nov 20. PMID: 31756327.

[5]Choi JH, Song NJ, Lee AR, Lee DH, Seo MJ, Kim S, Chang SH, Yang DK, Hwang YJ, Hwang KA, Ha TS, Yun UJ, Park KW. Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice. Int J Mol Sci. 2018 Dec 21;20(1):26. doi: 10.3390/ijms20010026. PMID: 30577593; PMCID: PMC6337118.

Oxyresveratrol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.94mL

8.19mL

4.09mL

Oxyresveratrol 技术信息

CAS号29700-22-9
分子式C14H12O4
分子量 244.243
别名 氧化白黎芦醇 ;trans-Oxyresveratrol;trans-2',3,4',5-Tetramethoxystilbene
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 50 mg/mL(204.71 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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